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Target
Sodium-dependent serotonin transporter
Ligand
BDBM50152960
Substrate
n/a
Meas. Tech.
ChEMBL_306337 (CHEMBL828157)
IC50
77±n/a nM
Citation
 Boy, KM; Dee, M; Yevich, J; Torrente, J; Gao, Q; Iben, L; Stark, A; Mattson, RJ Ligand conformation has a definitive effect on 5-HT1A and serotonin reuptake affinity. Bioorg Med Chem Lett 14:4467-70 (2004) [PubMed]  Article 
Target
Name:
Sodium-dependent serotonin transporter
Synonyms:
5-HT Transporter | 5HT transporter | 5HTT | HTT | SC6A4_HUMAN | SERT | SLC6A4 | Serotonin Transporter (SERT) | Serotonin transporter (5HTT) | Serotonin transporter protein (SERT) | Sodium-dependent serotonin transporter (SERT) | Solute carrier family 6 member 4
Type:
Multi-pass membrane protein
Mol. Mass.:
70322.51
Organism:
Homo sapiens (Human)
Description:
P31645
Residue:
630
Sequence:
METTPLNSQKQLSACEDGEDCQENGVLQKVVPTPGDKVESGQISNGYSAVPSPGAGDDTRHSIPATTTTLVAELHQGERETWGKKVDFLLSVIGYAVDLGNVWRFPYICYQNGGGAFLLPYTIMAIFGGIPLFYMELALGQYHRNGCISIWRKICPIFKGIGYAICIIAFYIASYYNTIMAWALYYLISSFTDQLPWTSCKNSWNTGNCTNYFSEDNITWTLHSTSPAEEFYTRHVLQIHRSKGLQDLGGISWQLALCIMLIFTVIYFSIWKGVKTSGKVVWVTATFPYIILSVLLVRGATLPGAWRGVLFYLKPNWQKLLETGVWIDAAAQIFFSLGPGFGVLLAFASYNKFNNNCYQDALVTSVVNCMTSFVSGFVIFTVLGYMAEMRNEDVSEVAKDAGPSLLFITYAEAIANMPASTFFAIIFFLMLITLGLDSTFAGLEGVITAVLDEFPHVWAKRRERFVLAVVITCFFGSLVTLTFGGAYVVKLLEEYATGPAVLTVALIEAVAVSWFYGITQFCRDVKEMLGFSPGWFWRICWVAISPLFLLFIICSFLMSPPQLRLFQYNYPYWSIILGYCIGTSSFICIPTYIAYRLIITPGTFKERIIKSITPETPTEIPCGDIRLNAV
  
Inhibitor
Name:
BDBM50152960
Synonyms:
4-[4-(2-bromo-5-fluorobenzyl)hexahydro-1-pyridinyl]spiro[cyclohexane-1,7''-(2'',3'',7'',9''-tetrahydro[1,4]dioxino[3,2-e]isobenzofuran)]-9''-one | CHEMBL362716
Type:
Small organic molecule
Emp. Form.:
C27H29BrFNO4
Mol. Mass.:
530.426
SMILES:
Fc1ccc(Br)c(CC2CCN(CC2)[C@H]2CC[C@]3(CC2)OC(=O)c2c3ccc3OCCOc23)c1 |wU:14.14,17.21,(8.23,.41,;8.02,-1.12,;9.26,-2.06,;9.05,-3.58,;7.62,-4.18,;7.41,-5.68,;6.41,-3.23,;4.98,-3.81,;3.77,-2.87,;2.34,-3.44,;1.13,-2.51,;1.32,-.97,;2.74,-.38,;3.98,-1.34,;.1,-.03,;-1.32,-.63,;-2.54,.3,;-2.35,1.86,;-.93,2.43,;.31,1.49,;-2.3,3.39,;-3.78,3.89,;-4.62,5.18,;-4.71,2.68,;-3.82,1.42,;-4.52,.04,;-6.04,-.08,;-6.93,1.17,;-8.45,1.09,;-9.3,2.36,;-8.62,3.74,;-7.09,3.82,;-6.25,2.56,;6.62,-1.69,)|
Structure:
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