Reaction Details Report a problem with these data
Target
Serine/threonine-protein kinase 4
Ligand
BDBM185456
Substrate
n/a
Meas. Tech.
ChEMBL_2158669 (CHEMBL5043419)
IC50
35±n/a nM
Citation
 Bata, N; Chaikuad, A; Bakas, NA; Limpert, AS; Lambert, LJ; Sheffler, DJ; Berger, LM; Liu, G; Yuan, C; Wang, L; Peng, Y; Dong, J; Celeridad, M; Layng, F; Knapp, S; Cosford, NDP Inhibitors of the Hippo Pathway Kinases STK3/MST2 and STK4/MST1 Have Utility for the Treatment of Acute Myeloid Leukemia. J Med Chem 65:1352-1369 (2022) [PubMed]  Article 
Target
Name:
Serine/threonine-protein kinase 4
Synonyms:
KRS2 | MST1 | STK4 | STK4_HUMAN | Serine/threonine-protein kinase 3/4 | Serine/threonine-protein kinase 4 (STK4) | Serine/threonine-protein kinase MST1
Type:
Enzyme
Mol. Mass.:
55611.40
Organism:
Homo sapiens (Human)
Description:
Q13043
Residue:
487
Sequence:
METVQLRNPPRRQLKKLDEDSLTKQPEEVFDVLEKLGEGSYGSVYKAIHKETGQIVAIKQVPVESDLQEIIKEISIMQQCDSPHVVKYYGSYFKNTDLWIVMEYCGAGSVSDIIRLRNKTLTEDEIATILQSTLKGLEYLHFMRKIHRDIKAGNILLNTEGHAKLADFGVAGQLTDTMAKRNTVIGTPFWMAPEVIQEIGYNCVADIWSLGITAIEMAEGKPPYADIHPMRAIFMIPTNPPPTFRKPELWSDNFTDFVKQCLVKSPEQRATATQLLQHPFVRSAKGVSILRDLINEAMDVKLKRQESQQREVDQDDEENSEEDEMDSGTMVRAVGDEMGTVRVASTMTDGANTMIEHDDTLPSQLGTMVINAEDEEEEGTMKRRDETMQPAKPSFLEYFEQKEKENQINSFGKSVPGPLKNSSDWKIPQDGDYEFLKSWTVEDLQKRLLALDPMMEQEIEEIRQKYQSKRQPILDAIEAKKRRQQNF
  
Inhibitor
Name:
BDBM185456
Synonyms:
US9156845, 107
Type:
Small organic molecule
Emp. Form.:
C17H18N4O
Mol. Mass.:
294.351
SMILES:
Cc1cccc(c1)-c1c[nH]c2ncnc(N3CCOCC3)c12
Structure:
Search PDB for entries with ligand similarity: