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Target
2-5A-dependent ribonuclease
Ligand
BDBM23448
Substrate
n/a
Meas. Tech.
ChEMBL_2158720 (CHEMBL5043470)
IC50
2400000±n/a nM
Citation
 Tang, J; Dong, B; Liu, M; Liu, S; Niu, X; Gaughan, C; Asthana, A; Zhou, H; Xu, Z; Zhang, G; Silverman, RH; Huang, H Identification of Small Molecule Inhibitors of RNase L by Fragment-Based Drug Discovery. J Med Chem 65:1445-1457 (2022) [PubMed]  Article 
Target
Name:
2-5A-dependent ribonuclease
Synonyms:
2-5A-dependent RNase | 2-5A-dependent ribonuclease | RN5A_HUMAN | RNASEL | RNS4 | RNase L | Ribonuclease 4 | Ribonuclease L
Type:
PROTEIN
Mol. Mass.:
83534.35
Organism:
Homo sapiens (Human)
Description:
ChEMBL_164152
Residue:
741
Sequence:
MESRDHNNPQEGPTSSSGRRAAVEDNHLLIKAVQNEDVDLVQQLLEGGANVNFQEEEGGWTPLHNAVQMSREDIVELLLRHGADPVLRKKNGATPFILAAIAGSVKLLKLFLSKGADVNECDFYGFTAFMEAAVYGKVKALKFLYKRGANVNLRRKTKEDQERLRKGGATALMDAAEKGHVEVLKILLDEMGADVNACDNMGRNALIHALLSSDDSDVEAITHLLLDHGADVNVRGERGKTPLILAVEKKHLGLVQRLLEQEHIEINDTDSDGKTALLLAVELKLKKIAELLCKRGASTDCGDLVMTARRNYDHSLVKVLLSHGAKEDFHPPAEDWKPQSSHWGAALKDLHRIYRPMIGKLKFFIDEKYKIADTSEGGIYLGFYEKQEVAVKTFCEGSPRAQREVSCLQSSRENSHLVTFYGSESHRGHLFVCVTLCEQTLEACLDVHRGEDVENEEDEFARNVLSSIFKAVQELHLSCGYTHQDLQPQNILIDSKKAAHLADFDKSIKWAGDPQEVKRDLEDLGRLVLYVVKKGSISFEDLKAQSNEEVVQLSPDEETKDLIHRLFHPGEHVRDCLSDLLGHPFFWTWESRYRTLRNVGNESDIKTRKSESEILRLLQPGPSEHSKSFDKWTTKINECVMKKMNKFYEKRGNFYQNTVGDLLKFIRNLGEHIDEEKHKKMKLKIGDPSLYFQKTFPDLVIYVYTKLQNTEYRKHFPQTHSPNKPQCDGAGGASGLASPGC
  
Inhibitor
Name:
BDBM23448
Synonyms:
BUTYLPARABEN | Butyl paraben | Nipabutyl | butyl 4-hydroxybenzoate | cid_7184
Type:
Small organic molecule
Emp. Form.:
C11H14O3
Mol. Mass.:
194.2271
SMILES:
CCCCOC(=O)c1ccc(O)cc1
Structure:
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