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Target
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
Ligand
BDBM50153166
Substrate
n/a
Meas. Tech.
ChEMBL_310170 (CHEMBL824826)
EC50
7.7±n/a nM
Citation
 Lin, NH; Wang, L; Wang, X; Wang, GT; Cohen, J; Gu, WZ; Zhang, H; Rosenberg, SH; Sham, HL Synthesis and biological evaluation of 1-benzyl-5-(3-biphenyl-2-yl-propyl)-1H-imidazole as novel farnesyltransferase inhibitor. Bioorg Med Chem Lett 14:5057-62 (2004) [PubMed]  Article 
Target
Name:
Protein farnesyltransferase subunit beta/geranylgeranyltransferase type-1 subunit alpha
Synonyms:
Protein farnesyltransferase | Protein farnesyltransferase beta/geranylgeranyltransferase type I alpha subunit
Type:
n/a
Mol. Mass.:
n/a
Description:
ASSAY_ID of EBI is 38702
Components:
This complex has 2 components.
Component 1
Name:
Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha
Synonyms:
CAAX farnesyltransferase subunit alpha | FNTA_MOUSE | FTase-alpha | Fnta | GGTase-I-alpha | Geranylgeranyl transferase type 1 | Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha | Ras proteins prenyltransferase subunit alpha | Type I protein geranyl-geranyltransferase subunit alpha
Type:
PROTEIN
Mol. Mass.:
43994.09
Organism:
Mus musculus
Description:
EBI_10570
Residue:
377
Sequence:
MAATEGVGESAAGGEPGQPEQPPPPPPPPPAQQPQEEEMAAEAGEAAASPMDDGFLSLDSPTYVLYRDRAEWADIDPVPQNDGPNPVVQIIYSEKFRDVYDYFRAVLQRDERSERAFKLTRDAIELNAANYTVWHFRRVLLRSLQKDLQEEMNYITAIIEEQPKNYQVWHHRRVLVEWLKDPSQELEFIADILSQDAKNYHAWQHRQWVIQEFRLWDNELQYVDQLLKEDVRNNSVWNQRHFVISNTTGYSDRAVLEREVQYTLEMIKLVPHNESAWNYLKGILQDRGLSRYPNLLNQLLDLQPSHSSPYLIAFLVDVYEDMLENQCDNKEDILNKALELCEILAKEKDTIRKEYWRYIGRSLQSKHCRESDIPASV
  
Component 2
Name:
Protein farnesyltransferase subunit beta
Synonyms:
FNTB_MOUSE | Fntb | Protein farnesyltransferase
Type:
PROTEIN
Mol. Mass.:
48811.61
Organism:
Mus musculus
Description:
EBI_12341
Residue:
437
Sequence:
MASSSSFTYYCPPSSSPVWSEPLYSLRPEHVRERLQDDSVETVTSIEQAKVEEKIQEVFSSYKFNHLVPRLILQREKHFHYLKRGLRQLTDAYECLDASRPWLCYWILHSLELLDEPIPQIVATDVCQFLELCQSPDGGFGGGPGQYPHLAPTYAAVNALCIIGTEEAYNVINREKLLQYLYSLKQPDGSFLMHVGGEVDVRSAYCAASVASLTNIITPDLFEGTAEWIARCQNWEGGIGGVPGMEAHGGYTFCGLAALVILKKERSLNLKSLLQWVTSRQMRFEGGFQGRCNKLVDGCYSFWQAGLLPLLHRALHAQGDPALSMSHWMFHQQALQEYILMCCQCPAGGLLDKPGKSRDFYHTCYCLSGLSIAQHFGSGAMLHDMVMGVPENVLQPTHPVYNIGPEKVIQATTHFLQKPVPGFEECEDEVTSDPATD
  
Inhibitor
Name:
BDBM50153166
Synonyms:
3''-Chloro-6-[3-(4-cyano-benzyl)-3H-imidazol-4-ylmethoxymethyl]-biphenyl-3-carbonitrile | 3'-chloro-6-(((1-(4-cyanobenzyl)-1H-imidazol-5-yl)methoxy)methyl)biphenyl-3-carbonitrile | CHEMBL186906
Type:
Small organic molecule
Emp. Form.:
C26H19ClN4O
Mol. Mass.:
438.908
SMILES:
Clc1cccc(c1)-c1cc(ccc1COCc1cncn1Cc1ccc(cc1)C#N)C#N
Structure:
Search PDB for entries with ligand similarity: