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Target
Caspase-3
Ligand
BDBM50153681
Substrate
n/a
Meas. Tech.
ChEBML_305435
IC50
61±n/a nM
Citation
 Cai, SX; Guan, L; Jia, S; Wang, Y; Yang, W; Tseng, B; Drewe, J Dipeptidyl aspartyl fluoromethylketones as potent caspase inhibitors: SAR of the N-protecting group. Bioorg Med Chem Lett 14:5295-300 (2004) [PubMed]  Article 
Target
Name:
Caspase-3
Synonyms:
Apopain | CASP-3 | CASP3 | CASP3_HUMAN | CPP-32 | CPP32 | Caspase 3 | Caspase-3 subunit p12 | Caspase-3 subunit p17 | Cysteine protease CPP32 | SCA-1 | SREBP cleavage activity 1 | Yama protein | caspase-3 preproprotein
Type:
Hydrolase; heterotetramer of two heterodimers
Mol. Mass.:
31607.55
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
277
Sequence:
MENTENSVDSKSIKNLEPKIIHGSESMDSGISLDNSYKMDYPEMGLCIIINNKNFHKSTGMTSRSGTDVDAANLRETFRNLKYEVRNKNDLTREEIVELMRDVSKEDHSKRSSFVCVLLSHGEEGIIFGTNGPVDLKKITNFFRGDRCRSLTGKPKLFIIQACRGTELDCGIETDSGVDDDMACHKIPVEADFLYAYSTAPGYYSWRNSKDGSWFIQSLCAMLKQYADKLEFMHILTRVNRKVATEFESFSFDATFHAKKQIPCIVSMLTKELYFYH
  
Inhibitor
Name:
BDBM50153681
Synonyms:
5-Fluoro-3-((S)-3-methyl-2-phenylacetylamino-butyrylamino)-4-oxo-pentanoic acid | CHEMBL425543
Type:
Small organic molecule
Emp. Form.:
C18H23FN2O5
Mol. Mass.:
366.384
SMILES:
CC(C)[C@H](NC(=O)Cc1ccccc1)C(=O)NC(CC(O)=O)C(=O)CF
Structure:
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