Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM50584890
Substrate
n/a
Meas. Tech.
ChEMBL_2160856 (CHEMBL5045606)
Ki
1700±n/a nM
Citation
 Wen, Z; Salmaso, V; Jung, YH; Phung, NB; Gopinatth, V; Shah, Q; Patterson, AT; Randle, JCR; Chen, Z; Salvemini, D; Lieberman, DI; Whitehead, GS; Karcz, TP; Cook, DN; Jacobson, KA Bridged Piperidine Analogues of a High Affinity Naphthalene-Based P2Y J Med Chem 65:3434-3459 (2022) [PubMed]  Article 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM50584890
Synonyms:
CHEMBL5079102
Type:
Small organic molecule
Emp. Form.:
C31H26F3NO3
Mol. Mass.:
517.5382
SMILES:
[H][C@]12CC[C@@]([H])(CNC1)C2(O)c1ccc(cc1)-c1cc(cc2cc(ccc12)-c1ccc(cc1)C(F)(F)F)C(O)=O |r|
Structure:
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