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Target
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma
Ligand
BDBM50584985
Substrate
n/a
Meas. Tech.
ChEMBL_2161062 (CHEMBL5045812)
IC50
631±n/a nM
Citation
 Boffey, HK; Rooney, TPC; Willems, HMG; Edwards, S; Green, C; Howard, T; Ogg, D; Romero, T; Scott, DE; Winpenny, D; Duce, J; Skidmore, J; Clarke, JH; Andrews, SP Development of Selective Phosphatidylinositol 5-Phosphate 4-Kinase ? Inhibitors with a Non-ATP-competitive, Allosteric Binding Mode. J Med Chem 65:3359-3370 (2022) [PubMed]  Article 
Target
Name:
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma
Synonyms:
PI(5)P 4-kinase type II gamma | PI42C_HUMAN | PIP4K2C | PIP4KII-gamma | PIP5K2C | Phosphatidylinositol-5-phosphate 4-kinase type II gamma | Phosphatidylinositol-5-phosphate 4-kinase type-2 gamma
Type:
PROTEIN
Mol. Mass.:
47302.35
Organism:
Homo sapiens (Human)
Description:
ChEMBL_774614
Residue:
421
Sequence:
MASSSVPPATVSAATAGPGPGFGFASKTKKKHFVQQKVKVFRAADPLVGVFLWGVAHSINELSQVPPPVMLLPDDFKASSKIKVNNHLFHRENLPSHFKFKEYCPQVFRNLRDRFGIDDQDYLVSLTRNPPSESEGSDGRFLISYDRTLVIKEVSSEDIADMHSNLSNYHQYIVKCHGNTLLPQFLGMYRVSVDNEDSYMLVMRNMFSHRLPVHRKYDLKGSLVSREASDKEKVKELPTLKDMDFLNKNQKVYIGEEEKKIFLEKLKRDVEFLVQLKIMDYSLLLGIHDIIRGSEPEEEAPVREDESEVDGDCSLTGPPALVGSYGTSPEGIGGYIHSHRPLGPGEFESFIDVYAIRSAEGAPQKEVYFMGLIDILTQYDAKKKAAHAAKTVKHGAGAEISTVHPEQYAKRFLDFITNIFA
  
Inhibitor
Name:
BDBM50584985
Synonyms:
CHEMBL5083265
Type:
Small organic molecule
Emp. Form.:
C23H22N4
Mol. Mass.:
354.4476
SMILES:
CC(C)c1ccccc1-c1nc(NCc2ccccn2)c2ccccc2n1
Structure:
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