Reaction Details Report a problem with these data
Target
Growth/differentiation factor 8
Ligand
BDBM50525413
Substrate
n/a
Meas. Tech.
ChEMBL_2161330 (CHEMBL5046080)
IC50
260±n/a nM
Citation
Takayama, K; Hitachi, K; Okamoto, H; Saitoh, M; Odagiri, M; Ohfusa, R; Shimada, T; Taguchi, A; Taniguchi, A; Tsuchida, K; Hayashi, Y Development of Myostatin Inhibitory d-Peptides to Enhance the Potency, Increasing Skeletal Muscle Mass in Mice. ACS Med Chem Lett 13:492-498 (2022) [PubMed] Article
More Info.:
Target
Name:
Growth/differentiation factor 8
Synonyms:
GDF-8 | GDF8 | GDF8_HUMAN | Growth/differentiation factor 8 | MSTN | Myostatin
Type:
PROTEIN
Mol. Mass.:
42750.72
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109584
Residue:
375
Sequence:
MQKLQLCVYIYLFMLIVAGPVDLNENSEQKENVEKEGLCNACTWRQNTKSSRIEAIKIQILSKLRLETAPNISKDVIRQLLPKAPPLRELIDQYDVQRDDSSDGSLEDDDYHATTETIITMPTESDFLMQVDGKPKCCFFKFSSKIQYNKVVKAQLWIYLRPVETPTTVFVQILRLIKPMKDGTRYTGIRSLKLDMNPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKALDENGHDLAVTFPGPGEDGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGECEFVFLQKYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS
Inhibitor
Name:
BDBM50525413
Synonyms:
CHEMBL4448117
Type:
Small organic molecule
Emp. Form.:
C114H173N29O19
Mol. Mass.:
2253.7763
SMILES:
CC[C@H](C)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12)[C@@H](C)CC)[C@@H](C)CC)C1CCCCC1)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C1CCCCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(N)=O |r|