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Target
Proteinase-activated receptor 1
Ligand
BDBM50585037
Substrate
n/a
Meas. Tech.
ChEMBL_2161343 (CHEMBL5046093)
IC50
3.0±n/a nM
Citation
 Mandal, M; Madeira, M; Amin, RP; Buevich, AV; Cheng, A; Labroli, M; Liu, X; Acton, J; Pio, B; Basso, A; Chobanian, H; Dong, G; Dropinski, J; Guo, Y; Guo, Z; Kurowski, S; Korfmacher, W; Lee, S; Meng, D; Ondeyka, D; Yang, Z; Zhang, R; Wei, H; Wu, Z; Zhang, F; Wollenberg, G; Biftu, T; Greenlee, WJ; Chintala, M; Maletic, M; Zhu, Z Lead Optimization to Advance Protease-Activated Receptor-1 Antagonists in Early Discovery. J Med Chem 65:5575-5592 (2022) [PubMed]  Article 
Target
Name:
Proteinase-activated receptor 1
Synonyms:
CF2R | Coagulation factor II receptor | F2R | PAR-1 | PAR1 | PAR1_HUMAN | Proteinase activated receptor 1 | Proteinase-activated receptor 1 (PAR-1) | TR | Thrombin receptor | Thrombin receptor/ Proteinase-activated receptor 1(Par-1)
Type:
Protein
Mol. Mass.:
47450.07
Organism:
Homo sapiens (Human)
Description:
P25116
Residue:
425
Sequence:
MGPRRLLLVAACFSLCGPLLSARTRARRPESKATNATLDPRSFLLRNPNDKYEPFWEDEEKNESGLTEYRLVSINKSSPLQKQLPAFISEDASGYLTSSWLTLFVPSVYTGVFVVSLPLNIMAIVVFILKMKVKKPAVVYMLHLATADVLFVSVLPFKISYYFSGSDWQFGSELCRFVTAAFYCNMYASILLMTVISIDRFLAVVYPMQSLSWRTLGRASFTCLAIWALAIAGVVPLLLKEQTIQVPGLNITTCHDVLNETLLEGYYAYYFSAFSAVFFFVPLIISTVCYVSIIRCLSSSAVANRSKKSRALFLSAAVFCIFIICFGPTNVLLIAHYSFLSHTSTTEAAYFAYLLCVCVSSISCCIDPLIYYYASSECQRYVYSILCCKESSDPSSYNSSGQLMASKMDTCSSNLNNSIYKKLLT
  
Inhibitor
Name:
BDBM50585037
Synonyms:
CHEMBL5085562
Type:
Small organic molecule
Emp. Form.:
C25H24F2N2O3
Mol. Mass.:
438.4665
SMILES:
[H][C@@]12[C@@H](C)OC(=O)[C@]1(O)CC(F)(F)[C@@H](C)[C@@H]2\C=C\c1ccc(cn1)-c1cccc(C)c1C#N |r|
Structure:
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