Reaction Details Report a problem with these data
Target
Cathepsin K
Ligand
BDBM50154150
Substrate
n/a
Meas. Tech.
ChEMBL_304938 (CHEMBL826967)
IC50
71±n/a nM
Citation
Tavares, FX; Deaton, DN; Miller, AB; Miller, LR; Wright, LL; Zhou, HQ Potent and selective ketoamide-based inhibitors of cysteine protease, cathepsin K. J Med Chem 47:5049-56 (2004) [PubMed] Article
More Info.:
Target
Name:
Cathepsin K
Synonyms:
CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:
Enzyme
Mol. Mass.:
36975.68
Organism:
Homo sapiens (Human)
Description:
P43235
Residue:
329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
Inhibitor
Name:
BDBM50154150
Synonyms:
CHEMBL363950 | {1-[2-(3,3-Dimethyl-butyl)-2H-pyrazol-3-ylaminooxalyl]-pentyl}-carbamic acid 1-ethyl-cyclobutylmethyl ester
Type:
Small organic molecule
Emp. Form.:
C24H40N4O4
Mol. Mass.:
448.5988
SMILES:
CCCC[C@H](NC(=O)OCC1(CC)CCC1)C(=O)C(=O)Nc1ccnn1CCC(C)(C)C