Reaction Details Report a problem with these data
Target
Cathepsin K
Ligand
BDBM50154186
Substrate
n/a
Meas. Tech.
ChEMBL_304939 (CHEMBL826968)
IC50
54±n/a nM
Citation
 Tavares, FX; Deaton, DN; Miller, LR; Wright, LL Ketoamide-based inhibitors of cysteine protease, cathepsin K: P3 modifications. J Med Chem 47:5057-68 (2004) [PubMed]  Article 
Target
Name:
Cathepsin K
Synonyms:
CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:
Enzyme
Mol. Mass.:
36975.68
Organism:
Homo sapiens (Human)
Description:
P43235
Residue:
329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
  
Inhibitor
Name:
BDBM50154186
Synonyms:
CHEMBL188603 | [1-(1-Phenyl-ethylaminooxalyl)-pentyl]-carbamic acid 1-(2-morpholin-4-yl-pyrimidin-4-yloxymethyl)-cyclobutylmethyl ester
Type:
Small organic molecule
Emp. Form.:
C30H41N5O6
Mol. Mass.:
567.6764
SMILES:
CCCC[C@H](NC(=O)OCC1(COc2ccnc(n2)N2CCOCC2)CCC1)C(=O)C(=O)N[C@H](C)c1ccccc1
Structure:
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