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Target
Vanin 1
Ligand
BDBM480928
Substrate
n/a
Meas. Tech.
ChEMBL_2162860 (CHEMBL5047721)
IC50
12±n/a nM
Citation
 Casimiro-Garcia, A; Allais, C; Brennan, A; Choi, C; Dower, G; Farley, KA; Fleming, M; Flick, A; Frisbie, RK; Hall, J; Hepworth, D; Jones, H; Knafels, JD; Kortum, S; Lovering, FE; Mathias, JP; Mohan, S; Morgan, PM; Parng, C; Parris, K; Pullen, N; Schlerman, F; Stansfield, J; Strohbach, JW; Vajdos, FF; Vincent, F; Wang, H; Wang, X; Webster, R; Wright, SW Discovery of a Series of Pyrimidine Carboxamides as Inhibitors of Vanin-1. J Med Chem 65:757-784 (2022) [PubMed]  Article 
Target
Name:
Vanin 1
Synonyms:
Q4KLZ0_RAT | Vnn1
Type:
PROTEIN
Mol. Mass.:
57001.97
Organism:
Rattus norvegicus
Description:
ChEMBL_120310
Residue:
512
Sequence:
MSLSRWLAWAAAFSVFCVLKVSSLDTFLAAVYEHAVILPKVTLLPVSHSEALALMNQNLDLLEGAILSAAKQGAHIIVTPEDGIYGVQFTRDTIYPYLEDIPDPQVNWIPCDNPERFGSTPVQERLSCLAKNNSIYVVANMGDKKPCNTSDSHCPPDGRFQYNTDVVFDSRGKLVARYHKQNLFMGEEQFNAPPEPEVVTFDTPFGKFGIFTCFDILFHDPAVTLVTEFQVDTILFPTAWMDVLPHLAAIEFHSAWAIGMGVNFLAANLHIPLRRMTGSGIYAPDSPRAFHYDRKTQEGKLLLAQLDSHPSHSPVNWTSYASSVEAPPTEKEEFRSFVFFDEFTFVELKGITGNYTVCQNDLCCHLSYQMSEKRADEVYALGAFDGLHTVEGQYHLQICILLKCKTTNLRTCGSSVDTASTRFEMFSLSGTFGTRYVFPEVLLSEVKLAPGEFQVLSDGRLVSLKPTSGPVLTVGLFGRLYEKDWASNASSDLIAHSLIIMLILAPIIHYLC
  
Inhibitor
Name:
BDBM480928
Synonyms:
8-oxa-2-azaspiro[4.5]dec l{2-[(pyrazin-2-ylmethyl)amino]pyrimidin-5-yl}methanone | US10906888, Example 142
Type:
Small organic molecule
Emp. Form.:
C18H22N6O2
Mol. Mass.:
354.4063
SMILES:
O=C(N1CCC2(C1)CCOCC2)c1cnc(NCc2cnccn2)nc1
Structure:
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