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Target
Programmed cell death 1 ligand 1
Ligand
BDBM50585842
Substrate
n/a
Meas. Tech.
ChEMBL_2164100 (CHEMBL5048961)
Kd
25±n/a nM
Citation
 Wang, T; Cai, S; Cheng, Y; Zhang, W; Wang, M; Sun, H; Guo, B; Li, Z; Xiao, Y; Jiang, S Discovery of Small-Molecule Inhibitors of the PD-1/PD-L1 Axis That Promote PD-L1 Internalization and Degradation. J Med Chem 65:3879-3893 (2022) [PubMed]  Article 
Target
Name:
Programmed cell death 1 ligand 1
Synonyms:
B7 homolog 1 | B7-H1 | B7H1 | B7H1 | CD274 | CD_antigen=CD274 | PD-L1 | PD1L1_HUMAN | PDCD1 ligand 1 | PDCD1L1 | PDCD1LG1 | PDL1 | Programmed cell death 1 ligand 1 | Programmed death ligand 1
Type:
PROTEIN
Mol. Mass.:
33278.49
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109807
Residue:
290
Sequence:
MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGGADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQSDTHLEET
  
Inhibitor
Name:
BDBM50585842
Synonyms:
CHEMBL5072692
Type:
Small organic molecule
Emp. Form.:
C24H24N4O2
Mol. Mass.:
400.473
SMILES:
Cc1c(cccc1-c1ccccc1)-c1nnc(Nc2cccc(CNCCO)c2)o1
Structure:
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