Reaction Details Report a problem with these data
Target
Histamine H2 receptor
Ligand
BDBM50586669
Substrate
n/a
Meas. Tech.
ChEMBL_2169496 (CHEMBL5054555)
Ki
22±n/a nM
Citation
 Tropmann, K; Seibel-Ehlert, U; Littmann, T; Strasser, A Shining light on the histamine H Bioorg Med Chem Lett 52:0 (2021) [PubMed]  Article 
Target
Name:
Histamine H2 receptor
Synonyms:
Gastric receptor I | H2R | HISTAMINE H2 | HRH2 | HRH2_HUMAN | Histamine H2 receptor | Histamine H2-Gs alpha S
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
40115.31
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
359
Sequence:
MAPNGTASSFCLDSTACKITITVVLAVLILITVAGNVVVCLAVGLNRRLRNLTNCFIVSLAITDLLLGLLVLPFSAIYQLSCKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRYCAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHTTSKCKVQVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAVMGAFIICWFPYFTAFVYRGLRGDDAINEVLEAIVLWLGYANSALNPILYAALNRDFRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKPLKLQVWSGTEVTAPQGATDR
  
Inhibitor
Name:
BDBM50586669
Synonyms:
CHEMBL5094663
Type:
Small organic molecule
Emp. Form.:
C47H66N9O2S
Mol. Mass.:
821.15
SMILES:
Cc1nc(N)sc1CCCN\C(N)=N\C(=O)NCCCCCCNC(=O)CCCCCN1\C(=C\C=C\C=C\C2=[N+](C)c3ccccc3C2(C)C)c2ccccc2C1(C)C |c:39|
Structure:
Search PDB for entries with ligand similarity: