Reaction Details Report a problem with these data
Target
Forkhead box protein M1
Ligand
BDBM50586851
Substrate
n/a
Meas. Tech.
ChEMBL_2169991 (CHEMBL5055050)
IC50
51400±n/a nM
Citation
 Luo, G; Lin, X; Vega-Medina, A; Xiao, M; Li, G; Wei, H; Velázquez-Martínez, CA; Xiang, H Targeting of the FOXM1 Oncoprotein by E3 Ligase-Assisted Degradation. J Med Chem 64:17098-17114 (2021) [PubMed]  Article 
Target
Name:
Forkhead box protein M1
Synonyms:
FKHL16 | FOXM1 | FOXM1_HUMAN | Forkhead box protein M1 | Forkhead-related protein FKHL16 | HFH-11 | HFH11 | HNF-3/fork-head homolog 11 | Hepatocyte nuclear factor 3 forkhead homolog 11 | M-phase phosphoprotein 2 | MPM-2 reactive phosphoprotein 2 | MPP2 | Transcription factor Trident | WIN | Winged-helix factor from INS-1 cells
Type:
PROTEIN
Mol. Mass.:
84290.86
Organism:
Homo sapiens
Description:
ChEMBL_120188
Residue:
763
Sequence:
MKTSPRRPLILKRRRLPLPVQNAPSETSEEEPKRSPAQQESNQAEASKEVAESNSCKFPAGIKIINHPTMPNTQVVAIPNNANIHSIITALTAKGKESGSSGPNKFILISCGGAPTQPPGLRPQTQTSYDAKRTEVTLETLGPKPAARDVNLPRPPGALCEQKRETCADGEAAGCTINNSLSNIQWLRKMSSDGLGSRSIKQEMEEKENCHLEQRQVKVEEPSRPSASWQNSVSERPPYSYMAMIQFAINSTERKRMTLKDIYTWIEDHFPYFKHIAKPGWKNSIRHNLSLHDMFVRETSANGKVSFWTIHPSANRYLTLDQVFKPLDPGSPQLPEHLESQQKRPNPELRRNMTIKTELPLGARRKMKPLLPRVSSYLVPIQFPVNQSLVLQPSVKVPLPLAASLMSSELARHSKRVRIAPKVLLAEEGIAPLSSAGPGKEEKLLFGEGFSPLLPVQTIKEEEIQPGEEMPHLARPIKVESPPLEEWPSPAPSFKEESSHSWEDSSQSPTPRPKKSYSGLRSPTRCVSEMLVIQHRERRERSRSRRKQHLLPPCVDEPELLFSEGPSTSRWAAELPFPADSSDPASQLSYSQEVGGPFKTPIKETLPISSTPSKSVLPRTPESWRLTPPAKVGGLDFSPVQTSQGASDPLPDPLGLMDLSTTPLQSAPPLESPQRLLSSEPLDLISVPFGNSSPSDIDVPKPGSPEPQVSGLAANRSLTEGLVLDTMNDSLSKILLDISFPGLDEDPLGPDNINWSQFIPELQ
  
Inhibitor
Name:
BDBM50586851
Synonyms:
CHEMBL5085941
Type:
Small organic molecule
Emp. Form.:
C42H37F4N7O9S
Mol. Mass.:
891.843
SMILES:
Nc1c(sc2nc(cc(c12)C(F)(F)F)-c1ccc(OCC(=O)NCCOCCOCCNc2cccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c23)cc1)C(=O)Nc1ccc(F)cc1
Structure:
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