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Target
Pantothenate kinase 3
Ligand
BDBM50586875
Substrate
n/a
Meas. Tech.
ChEMBL_2170243 (CHEMBL5055302)
IC50
990±n/a nM
Citation
 Sharma, LK; Yun, MK; Subramanian, C; Tangallapally, R; Jackowski, S; Rock, CO; White, SW; Lee, RE LipE guided discovery of isopropylphenyl pyridazines as pantothenate kinase modulators. Bioorg Med Chem 52:0 (2021) [PubMed]  Article 
Target
Name:
Pantothenate kinase 3
Synonyms:
PANK3 | PANK3_HUMAN | Pantothenate kinase 3 | Pantothenic acid kinase 3 | hPanK3
Type:
PROTEIN
Mol. Mass.:
41093.59
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109587
Residue:
370
Sequence:
MKIKDAKKPSFPWFGMDIGGTLVKLSYFEPIDITAEEEQEEVESLKSIRKYLTSNVAYGSTGIRDVHLELKDLTLFGRRGNLHFIRFPTQDLPTFIQMGRDKNFSTLQTVLCATGGGAYKFEKDFRTIGNLHLHKLDELDCLVKGLLYIDSVSFNGQAECYYFANASEPERCQKMPFNLDDPYPLLVVNIGSGVSILAVHSKDNYKRVTGTSLGGGTFLGLCSLLTGCESFEEALEMASKGDSTQADKLVRDIYGGDYERFGLPGWAVASSFGNMIYKEKRESVSKEDLARATLVTITNNIGSVARMCAVNEKINRVVFVGNFLRVNTLSMKLLAYALDYWSKGQLKALFLEHEGYFGAVGALLGLPNFS
  
Inhibitor
Name:
BDBM50586875
Synonyms:
CHEMBL5086368
Type:
Small organic molecule
Emp. Form.:
C21H24N4O2
Mol. Mass.:
364.4409
SMILES:
CC(C)c1ccc(cc1)C(O)C(=O)N1CCN(CC1)c1ccc(cn1)C#N
Structure:
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