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Target
Peroxisome proliferator-activated receptor gamma
Ligand
BDBM50586966
Substrate
n/a
Meas. Tech.
ChEMBL_2170255 (CHEMBL5055314)
EC50
3200±n/a nM
Citation
 Lillich, FF; Willems, S; Ni, X; Kilu, W; Borkowsky, C; Brodsky, M; Kramer, JS; Brunst, S; Hernandez-Olmos, V; Heering, J; Schierle, S; Kestner, RI; Mayser, FM; Helmstädter, M; Göbel, T; Weizel, L; Namgaladze, D; Kaiser, A; Steinhilber, D; Pfeilschifter, W; Kahnt, AS; Proschak, A; Chaikuad, A; Knapp, S; Merk, D; Proschak, E Structure-Based Design of Dual Partial Peroxisome Proliferator-Activated Receptor ? Agonists/Soluble Epoxide Hydrolase Inhibitors. J Med Chem 64:17259-17276 (2021) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor gamma
Synonyms:
NR1C3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG | PPARG_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma (PPAR gamma) | Peroxisome proliferator-activated receptor gamma (PPARG) | Peroxisome proliferator-activated receptor gamma (PPARγ) | Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2 | peroxisome proliferator-activated receptor gamma isoform 2
Type:
Nuclear Receptor
Mol. Mass.:
57613.46
Organism:
Homo sapiens (Human)
Description:
P37231
Residue:
505
Sequence:
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
  
Inhibitor
Name:
BDBM50586966
Synonyms:
CHEMBL5091134
Type:
Small organic molecule
Emp. Form.:
C25H25F3N2O4S
Mol. Mass.:
506.537
SMILES:
FC(F)(F)c1cc(CS(=O)(=O)C2CC2)ccc1CNC(=O)c1ccc2n(CC3COC3)ccc2c1
Structure:
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