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Target
Heme oxygenase 1
Ligand
BDBM50315702
Substrate
n/a
Meas. Tech.
ChEMBL_2171316 (CHEMBL5056450)
IC50
270±n/a nM
Citation
 Fallica, AN; Sorrenti, V; D'Amico, AG; Salerno, L; Romeo, G; Intagliata, S; Consoli, V; Floresta, G; Rescifina, A; D'Agata, V; Vanella, L; Pittalą, V Discovery of Novel Acetamide-Based Heme Oxygenase-1 Inhibitors with Potent  J Med Chem 64:13373-13393 (2021) [PubMed]  Article 
Target
Name:
Heme oxygenase 1
Synonyms:
HMOX1_RAT | HSP32 | Heme Oxygenase 1 (HO-1) | Heme oxygenase 1 | Hmox1
Type:
Enzyme
Mol. Mass.:
33005.15
Organism:
Rattus norvegicus (rat)
Description:
HO-1 obtained from rat spleen was used in enzyme assays.
Residue:
289
Sequence:
MERPQLDSMSQDLSEALKEATKEVHIRAENSEFMRNFQKGQVSREGFKLVMASLYHIYTALEEEIERNKQNPVYAPLYFPEELHRRAALEQDMAFWYGPHWQEAIPYTPATQHYVKRLHEVGGTHPELLVAHAYTRYLGDLSGGQVLKKIAQKAMALPSSGEGLAFFTFPSIDNPTKFKQLYRARMNTLEMTPEVKHRVTEEAKTAFLLNIELFEELQALLTEEHKDQSPSQTEFLRQRPASLVQDTTSAETPRGKSQISTSSSQTPLLRWVLTLSFLLATVAVGIYAM
  
Inhibitor
Name:
BDBM50315702
Synonyms:
CHEMBL4166126
Type:
Small organic molecule
Emp. Form.:
C19H18N2O
Mol. Mass.:
290.359
SMILES:
O=C(CC(c1ccccc1)c1ccccc1)Cn1ccnc1
Structure:
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