Reaction Details Report a problem with these data
Target
Transient receptor potential cation channel subfamily V member 5
Ligand
BDBM50511105
Substrate
n/a
Meas. Tech.
ChEMBL_2184526 (CHEMBL5096608)
IC50
4800±n/a nM
Citation
 Sampson, PB Phytocannabinoid Pharmacology: Medicinal Properties of  J Nat Prod 84:142-160 (2021) [PubMed] 
Target
Name:
Transient receptor potential cation channel subfamily V member 5
Synonyms:
CaT2 | Calcium transport protein 2 | ECAC1 | ECaC | Epithelial calcium channel 1 | OTRPC3 | Osm-9-like TRP channel 3 | TRPV5 | TRPV5_HUMAN | Transient receptor potential cation channel subfamily V member 5
Type:
PROTEIN
Mol. Mass.:
82548.73
Organism:
Homo sapiens
Description:
ChEMBL_103793
Residue:
729
Sequence:
MGGFLPKAEGPGSQLQKLLPSFLVREQDWDQHLDKLHMLQQKRILESPLLRASKENDLSVLRQLLLDCTCDVRQRGALGETALHIAALYDNLEAALVLMEAAPELVFEPTTCEAFAGQTALHIAVVNQNVNLVRALLTRRASVSARATGTAFRRSPRNLIYFGEHPLSFAACVNSEEIVRLLIEHGADIRAQDSLGNTVLHILILQPNKTFACQMYNLLLSYDGHGDHLQPLDLVPNHQGLTPFKLAGVEGNTVMFQHLMQKRRHIQWTYGPLTSILYDLTEIDSWGEELSFLELVVSSDKREARQILEQTPVKELVSFKWNKYGRPYFCILAALYLLYMICFTTCCVYRPLKFRGGNRTHSRDITILQQKLLQEAYETREDIIRLVGELVSIVGAVIILLLEIPDIFRVGASRYFGKTILGGPFHVIIITYASLVLVTMVMRLTNTNGEVVPMSFALVLGWCSVMYFTRGFQMLGPFTIMIQKMIFGDLMRFCWLMAVVILGFASAFYIIFQTEDPTSLGQFYDYPMALFTTFELFLTVIDAPANYDVDLPFMFSIVNFAFAIIATLLMLNLFIAMMGDTHWRVAQERDELWRAQVVATTVMLERKLPRCLWPRSGICGCEFGLGDRWFLRVENHNDQNPLRVLRYVEVFKNSDKEDDQEHPSEKQPSGAESGTLARASLALPTSSLSRTASQSSSHRGWEILRQNTLGHLNLGLNLSEGDGEEVYHF
  
Inhibitor
Name:
BDBM50511105
Synonyms:
GWP-42004 | Gwp42004 | O-4394 | THCV | Tetrahydrocannabivarin
Type:
Small organic molecule
Emp. Form.:
C19H26O2
Mol. Mass.:
286.4085
SMILES:
[H][C@@]12C=C(C)CC[C@@]1([H])C(C)(C)Oc1cc(CCC)cc(O)c21 |r,t:2|
Structure:
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