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Target
Programmed cell death 1 ligand 1
Ligand
BDBM50587706
Substrate
n/a
Meas. Tech.
ChEMBL_2184684 (CHEMBL5096766)
IC50
37±n/a nM
Citation
 Pan, C; Yang, H; Lu, Y; Hu, S; Wu, Y; He, Q; Dong, X Recent advance of peptide-based molecules and nonpeptidic small-molecules modulating PD-1/PD-L1 protein-protein interaction or targeting PD-L1 protein degradation. Eur J Med Chem 213:0 (2021) [PubMed] 
Target
Name:
Programmed cell death 1 ligand 1
Synonyms:
B7 homolog 1 | B7-H1 | B7H1 | B7H1 | CD274 | CD_antigen=CD274 | PD-L1 | PD1L1_HUMAN | PDCD1 ligand 1 | PDCD1L1 | PDCD1LG1 | PDL1 | Programmed cell death 1 ligand 1 | Programmed death ligand 1
Type:
PROTEIN
Mol. Mass.:
33278.49
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109807
Residue:
290
Sequence:
MRIFAVFIFMTYWHLLNAFTVTVPKDLYVVEYGSNMTIECKFPVEKQLDLAALIVYWEMEDKNIIQFVHGEEDLKVQHSSYRQRARLLKDQLSLGNAALQITDVKLQDAGVYRCMISYGGADYKRITVKVNAPYNKINQRILVVDPVTSEHELTCQAEGYPKAEVIWTSSDHQVLSGKTTTTNSKREEKLFNVTSTLRINTTTNEIFYCTFRRLDPEENHTAELVIPELPLAHPPNERTHLVILGAILLCLGVALTFIFRLRKGRMMDVKKCGIQDTNSKKQSDTHLEET
  
Inhibitor
Name:
BDBM50587706
Synonyms:
CHEMBL5197008
Type:
Small organic molecule
Emp. Form.:
C12H20N6O6S
Mol. Mass.:
376.389
SMILES:
CC(O)[C@H](NC(=O)N[C@@H](CC(N)=O)c1nnc(s1)[C@@H](N)CO)C(O)=O |r|
Structure:
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