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Target
cAMP-dependent protein kinase catalytic subunit gamma
Ligand
BDBM50587770
Substrate
n/a
Meas. Tech.
ChEMBL_2185221 (CHEMBL5097303)
IC50
2.6±n/a nM
Citation
 Lee, S; Kim, J; Jo, J; Chang, JW; Sim, J; Yun, H Recent advances in development of hetero-bivalent kinase inhibitors. Eur J Med Chem 216:0 (2021) [PubMed] 
Target
Name:
cAMP-dependent protein kinase catalytic subunit gamma
Synonyms:
KAPCG_HUMAN | PKA C-gamma | PRKACG | cAMP-dependent protein kinase (PKA) | cAMP-dependent protein kinase catalytic subunit gamma
Type:
PROTEIN
Mol. Mass.:
40442.03
Organism:
Homo sapiens (Human)
Description:
ChEMBL_104720
Residue:
351
Sequence:
MGNAPAKKDTEQEESVNEFLAKARGDFLYRWGNPAQNTASSDQFERLRTLGMGSFGRVMLVRHQETGGHYAMKILNKQKVVKMKQVEHILNEKRILQAIDFPFLVKLQFSFKDNSYLYLVMEYVPGGEMFSRLQRVGRFSEPHACFYAAQVVLAVQYLHSLDLIHRDLKPENLLIDQQGYLQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAVGFPPFYADQPIQIYEKIVSGRVRFPSKLSSDLKHLLRSLLQVDLTKRFGNLRNGVGDIKNHKWFATTSWIAIYEKKVEAPFIPKYTGPGDASNFDDYEEEELRISINEKCAKEFSEF
  
Inhibitor
Name:
BDBM50587770
Synonyms:
CHEMBL5188493
Type:
Small organic molecule
Emp. Form.:
C88H115N19O21S2
Mol. Mass.:
1839.099
SMILES:
CO[C@@H]1[C@@H](C[C@H]2O[C@]1(C)n1c3ccccc3c3c4CNC(=O)c4c4c5ccccc5n2c4c13)N(C)C(=O)CCC(=O)NCCCOCCOCCOCCCNC(=O)COCC(=O)N[C@H]1CSSC[C@H](NC(=O)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC1=O)[C@@H](C)O)C(C)C)C(=O)NCC(N)=O |r,THB:16:32:6:2.3.4,23:31:6:2.3.4,10:9:6:2.3.4,29:30:6:2.3.4|
Structure:
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