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Target
Serine/threonine-protein kinase haspin
Ligand
BDBM50587781
Substrate
n/a
Meas. Tech.
ChEMBL_2185234 (CHEMBL5097316)
Kd
4.0±n/a nM
Citation
 Lee, S; Kim, J; Jo, J; Chang, JW; Sim, J; Yun, H Recent advances in development of hetero-bivalent kinase inhibitors. Eur J Med Chem 216:0 (2021) [PubMed] 
Target
Name:
Serine/threonine-protein kinase haspin
Synonyms:
GSG2 | Germ cell-specific gene 2 protein | H-haspin | HASPIN | HASP_HUMAN | Haploid germ cell-specific nuclear protein kinase
Type:
PROTEIN
Mol. Mass.:
88531.28
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1510616
Residue:
798
Sequence:
MAASLPGPGSRLFRTYGAADGRRQRRPGREAAQWFPPQDRRRFFNSSGSSDASIGDPSQSDDPDDPDDPDFPGSPVRRRRRRPGGRVPKDRPSLTVTPKRWKLRARPSLTVTPRRLGLRARPPQKCSTPCGPLRLPPFPSRDSGRLSPDLSVCGQPRDGDELGISASLFSSLASPCPGSPTPRDSVISIGTSACLVAASAVPSGLHLPEVSLDRASLPCSQEEATGGAKDTRMVHQTRASLRSVLFGLMNSGTPEDSEFRADGKNMRESCCKRKLVVGNGPEGPGLSSTGKRRATGQDSCQERGLQEAVRREHQEASVPKGRIVPRGIDRLERTRSSRKSKHQEATETSLLHSHRFKKGQKLGKDSFPTQDLTPLQNVCFWTKTRASFSFHKKKIVTDVSEVCSIYTTATSLSGSLLSECSNRPVMNRTSGAPSSWHSSSMYLLSPLNTLSISNKKASDAEKVYGECSQKGPVPFSHCLPTEKLQRCEKIGEGVFGEVFQTIADHTPVAIKIIAIEGPDLVNGSHQKTFEEILPEIIISKELSLLSGEVCNRTEGFIGLNSVHCVQGSYPPLLLKAWDHYNSTKGSANDRPDFFKDDQLFIVLEFEFGGIDLEQMRTKLSSLATAKSILHQLTASLAVAEASLRFEHRDLHWGNVLLKKTSLKKLHYTLNGKSSTIPSCGLQVSIIDYTLSRLERDGIVVFCDVSMDEDLFTGDGDYQFDIYRLMKKENNNRWGEYHPYSNVLWLHYLTDKMLKQMTFKTKCNTPAMKQIKRKIQEFHRTMLNFSSATDLLCQHSLFK
  
Inhibitor
Name:
BDBM50587781
Synonyms:
CHEMBL5169980
Type:
Small organic molecule
Emp. Form.:
C11H11IN4O5
Mol. Mass.:
406.1333
SMILES:
Nc1ncnc2n(cc(I)c12)[C@@H]1O[C@@H]([C@@H](O)[C@H]1O)C(O)=O |r|
Structure:
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