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Target
Tubulin beta-1 chain
Ligand
BDBM50070103
Substrate
n/a
Meas. Tech.
ChEMBL_305199 (CHEMBL832453)
IC50
10000±n/a nM
Citation
 Ducki, S; Mackenzie, G; Lawrence, NJ; Snyder, JP Quantitative structure-activity relationship (5D-QSAR) study of combretastatin-like analogues as inhibitors of tubulin assembly. J Med Chem 48:457-65 (2005) [PubMed]  Article 
Target
Name:
Tubulin beta-1 chain
Synonyms:
TBB1_HUMAN | TUBB1
Type:
PROTEIN
Mol. Mass.:
50311.77
Organism:
Homo sapiens (Human)
Description:
ChEMBL_305173
Residue:
451
Sequence:
MREIVHIQIGQCGNQIGAKFWEMIGEEHGIDLAGSDRGASALQLERISVYYNEAYGRKYVPRAVLVDLEPGTMDSIRSSKLGALFQPDSFVHGNSGAGNNWAKGHYTEGAELIENVLEVVRHESESCDCLQGFQIVHSLGGGTGSGMGTLLMNKIREEYPDRIMNSFSVMPSPKVSDTVVEPYNAVLSIHQLIENADACFCIDNEALYDICFRTLKLTTPTYGDLNHLVSLTMSGITTSLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTAQGSQQYRALSVAELTQQMFDARNTMAACDLRRGRYLTVACIFRGKMSTKEVDQQLLSVQTRNSSCFVEWIPNNVKVAVCDIPPRGLSMAATFIGNNTAIQEIFNRVSEHFSAMFKRKAFVHWYTSEGMDINEFGEAENNIHDLVSEYQQFQDAKAVLEEDEEVTEEAEMEPEDKGH
  
Inhibitor
Name:
BDBM50070103
Synonyms:
(E)-1-(2',5'-Dimethoxyphenyl)-3-(4''-N,N-Dimethylaminophenyl)-2-methylprop-2-en-1-one | (E)-1-(2,5-Dimethoxy-phenyl)-3-(4-dimethylamino-phenyl)-2-methyl-propenone | 1-(2,5-Dimethoxy-phenyl)-3-(4-dimethylamino-phenyl)-2-methyl-propenone | CHEMBL9652
Type:
Small organic molecule
Emp. Form.:
C20H23NO3
Mol. Mass.:
325.4015
SMILES:
COc1ccc(OC)c(c1)C(=O)C(\C)=C\c1ccc(cc1)N(C)C
Structure:
Search PDB for entries with ligand similarity: