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Target
Tubulin beta-1 chain
Ligand
BDBM50159312
Substrate
n/a
Meas. Tech.
ChEMBL_305199 (CHEMBL832453)
IC50
1700±n/a nM
Citation
 Ducki, S; Mackenzie, G; Lawrence, NJ; Snyder, JP Quantitative structure-activity relationship (5D-QSAR) study of combretastatin-like analogues as inhibitors of tubulin assembly. J Med Chem 48:457-65 (2005) [PubMed]  Article 
Target
Name:
Tubulin beta-1 chain
Synonyms:
TBB1_HUMAN | TUBB1
Type:
PROTEIN
Mol. Mass.:
50311.77
Organism:
Homo sapiens (Human)
Description:
ChEMBL_305173
Residue:
451
Sequence:
MREIVHIQIGQCGNQIGAKFWEMIGEEHGIDLAGSDRGASALQLERISVYYNEAYGRKYVPRAVLVDLEPGTMDSIRSSKLGALFQPDSFVHGNSGAGNNWAKGHYTEGAELIENVLEVVRHESESCDCLQGFQIVHSLGGGTGSGMGTLLMNKIREEYPDRIMNSFSVMPSPKVSDTVVEPYNAVLSIHQLIENADACFCIDNEALYDICFRTLKLTTPTYGDLNHLVSLTMSGITTSLRFPGQLNADLRKLAVNMVPFPRLHFFMPGFAPLTAQGSQQYRALSVAELTQQMFDARNTMAACDLRRGRYLTVACIFRGKMSTKEVDQQLLSVQTRNSSCFVEWIPNNVKVAVCDIPPRGLSMAATFIGNNTAIQEIFNRVSEHFSAMFKRKAFVHWYTSEGMDINEFGEAENNIHDLVSEYQQFQDAKAVLEEDEEVTEEAEMEPEDKGH
  
Inhibitor
Name:
BDBM50159312
Synonyms:
(Z)-3-(3'',5''-Difluoro-4''-methoxyphenyl)-2-methoxy-1-(3',4',5'-trimethoxyphenyl)prop-2-en-1-one | (Z)-3-(3,5-Difluoro-4-methoxy-phenyl)-2-methoxy-1-(3,4,5-trimethoxy-phenyl)-propenone | CHEMBL194925
Type:
Small organic molecule
Emp. Form.:
C20H20F2O6
Mol. Mass.:
394.366
SMILES:
CO\C(=C/c1cc(F)c(OC)c(F)c1)C(=O)c1cc(OC)c(OC)c(OC)c1
Structure:
Search PDB for entries with ligand similarity: