Reaction Details Report a problem with these data
Target
Amine oxidase [flavin-containing] A
Ligand
BDBM50159380
Substrate
n/a
Meas. Tech.
ChEMBL_302457 (CHEMBL875207)
Ki
4500±n/a nM
Citation
 Reck, F; Zhou, F; Girardot, M; Kern, G; Eyermann, CJ; Hales, NJ; Ramsay, RR; Gravestock, MB Identification of 4-substituted 1,2,3-triazoles as novel oxazolidinone antibacterial agents with reduced activity against monoamine oxidase A. J Med Chem 48:499-506 (2005) [PubMed]  Article 
Target
Name:
Amine oxidase [flavin-containing] A
Synonyms:
AOFA_HUMAN | Amine oxidase (flavin-containing) A | MAO-A | MAOA | Monoamine oxidase | Monoamine oxidase type A | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAO A) | Monoamine oxidase type A (MAOA)
Type:
Protein
Mol. Mass.:
59689.53
Organism:
Homo sapiens (Human)
Description:
P21397
Residue:
527
Sequence:
MENQEKASIAGHMFDVVVIGGGISGLSAAKLLTEYGVSVLVLEARDRVGGRTYTIRNEHVDYVDVGGAYVGPTQNRILRLSKELGIETYKVNVSERLVQYVKGKTYPFRGAFPPVWNPIAYLDYNNLWRTIDNMGKEIPTDAPWEAQHADKWDKMTMKELIDKICWTKTARRFAYLFVNINVTSEPHEVSALWFLWYVKQCGGTTRIFSVTNGGQERKFVGGSGQVSERIMDLLGDQVKLNHPVTHVDQSSDNIIIETLNHEHYECKYVINAIPPTLTAKIHFRPELPAERNQLIQRLPMGAVIKCMMYYKEAFWKKKDYCGCMIIEDEDAPISITLDDTKPDGSLPAIMGFILARKADRLAKLHKEIRKKKICELYAKVLGSQEALHPVHYEEKNWCEEQYSGGCYTAYFPPGIMTQYGRVIRQPVGRIFFAGTETATKWSGYMEGAVEAGERAAREVLNGLGKVTEKDIWVQEPESKDVPAVEITHTFWERNLPSVSGLLKIIGFSTSVTALGFVLYKYKLLPRS
  
Inhibitor
Name:
BDBM50159380
Synonyms:
(R)-3-[4-(1,1-Dioxo-1,2,3,6-tetrahydro-1lambda*6*-thiopyran-4-yl)-3-fluoro-phenyl]-5-(5-methyl-[1,2,3]triazol-1-ylmethyl)-oxazolidin-2-one | CHEMBL368870
Type:
Small organic molecule
Emp. Form.:
C18H19FN4O4S
Mol. Mass.:
406.431
SMILES:
Cc1cnnn1C[C@H]1CN(C(=O)O1)c1ccc(C2=CCS(=O)(=O)CC2)c(F)c1 |t:19|
Structure:
Search PDB for entries with ligand similarity: