Reaction Details Report a problem with these data
Target
Transthyretin
Ligand
BDBM50588575
Substrate
n/a
Meas. Tech.
ChEMBL_2187567 (CHEMBL5099649)
Kd
6.2±n/a nM
Citation
 Pinheiro, F; Pallarès, I; Peccati, F; Sánchez-Morales, A; Varejão, N; Bezerra, F; Ortega-Alarcon, D; Gonzalez, D; Osorio, M; Navarro, S; Velázquez-Campoy, A; Almeida, MR; Reverter, D; Busqué, F; Alibés, R; Sodupe, M; Ventura, S Development of a Highly Potent Transthyretin Amyloidogenesis Inhibitor: Design, Synthesis, and Evaluation. J Med Chem 65:14673-14691 (2022) [PubMed] 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM50588575
Synonyms:
CHEMBL5203058
Type:
Small organic molecule
Emp. Form.:
C13H8FNO6
Mol. Mass.:
293.2041
SMILES:
Oc1cc(F)cc(c1)C(=O)c1cc(O)c(O)c(c1)[N+]([O-])=O
Structure:
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