Reaction Details Report a problem with these data
Target
Adenosine receptor A1
Ligand
BDBM50159716
Substrate
n/a
Meas. Tech.
ChEMBL_303037 (CHEMBL828865)
Ki
110±n/a nM
Citation
 Yao, G; Haque, S; Sha, L; Kumaravel, G; Wang, J; Engber, TM; Whalley, ET; Conlon, PR; Chang, H; Kiesman, WF; Petter, RC Synthesis of alkyne derivatives of a novel triazolopyrazine as A(2A) adenosine receptor antagonists. Bioorg Med Chem Lett 15:511-5 (2005) [PubMed]  Article 
Target
Name:
Adenosine receptor A1
Synonyms:
AA1R_RAT | ADENOSINE A1 | ADENOSINE A1 high | ADENOSINE A1 low | Adenosine A1 receptor (A1) | Adenosine receptor | Adenosine receptors A1 | Adora1
Type:
Protein
Mol. Mass.:
36704.13
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
326
Sequence:
MPPYISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSVVEQDWRANGSVGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTFLKIWNDHFRCQPKPPIDEDLPEEKAED
  
Inhibitor
Name:
BDBM50159716
Synonyms:
4-(8-Amino-2-furan-2-yl-[1,2,4]triazolo[1,5-a]pyrazin-6-yl)-2-[4-(2H-imidazol-1-yl)-phenyl]-but-3-yn-2-ol | CHEMBL182486
Type:
Small organic molecule
Emp. Form.:
C22H18N7O2
Mol. Mass.:
412.4235
SMILES:
CC(O)(C#Cc1cn2nc(nc2c(N)n1)-c1ccco1)c1ccc(cc1)[N+]1=CC=NC1 |c:32,t:30|
Structure:
Search PDB for entries with ligand similarity: