Reaction Details Report a problem with these data
Target
Adenosine receptor A1
Ligand
BDBM50159713
Substrate
n/a
Meas. Tech.
ChEMBL_303037 (CHEMBL828865)
Ki
100±n/a nM
Citation
 Yao, G; Haque, S; Sha, L; Kumaravel, G; Wang, J; Engber, TM; Whalley, ET; Conlon, PR; Chang, H; Kiesman, WF; Petter, RC Synthesis of alkyne derivatives of a novel triazolopyrazine as A(2A) adenosine receptor antagonists. Bioorg Med Chem Lett 15:511-5 (2005) [PubMed]  Article 
Target
Name:
Adenosine receptor A1
Synonyms:
AA1R_RAT | ADENOSINE A1 | ADENOSINE A1 high | ADENOSINE A1 low | Adenosine A1 receptor (A1) | Adenosine receptor | Adenosine receptors A1 | Adora1
Type:
Protein
Mol. Mass.:
36704.13
Organism:
Rattus norvegicus (rat)
Description:
n/a
Residue:
326
Sequence:
MPPYISAFQAAYIGIEVLIALVSVPGNVLVIWAVKVNQALRDATFCFIVSLAVADVAVGALVIPLAILINIGPQTYFHTCLMVACPVLILTQSSILALLAIAVDRYLRVKIPLRYKTVVTQRRAAVAIAGCWILSLVVGLTPMFGWNNLSVVEQDWRANGSVGEPVIKCEFEKVISMEYMVYFNFFVWVLPPLLLMVLIYLEVFYLIRKQLNKKVSASSGDPQKYYGKELKIAKSLALILFLFALSWLPLHILNCITLFCPTCQKPSILIYIAIFLTHGNSAMNPIVYAFRIHKFRVTFLKIWNDHFRCQPKPPIDEDLPEEKAED
  
Inhibitor
Name:
BDBM50159713
Synonyms:
4-(8-Amino-2-furan-2-yl-[1,2,4]triazolo[1,5-a]pyrazin-6-yl)-2-methyl-1-pyridin-4-yl-but-3-yn-2-ol | 4-(8-amino-2-(furan-2-yl)-[1,2,4]triazolo[1,5-a]pyrazin-6-yl)-2-methyl-1-(pyridin-4-yl)but-3-yn-2-ol | CHEMBL359463
Type:
Small organic molecule
Emp. Form.:
C19H16N6O2
Mol. Mass.:
360.3693
SMILES:
CC(O)(Cc1ccncc1)C#Cc1cn2nc(nc2c(N)n1)-c1ccco1
Structure:
Search PDB for entries with ligand similarity: