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Target
Calcium/calmodulin-dependent protein kinase type II subunit alpha
Ligand
BDBM50228744
Substrate
n/a
Meas. Tech.
ChEMBL_2187920 (CHEMBL5100002)
IC50
1810±n/a nM
Citation
 Tian, Y; Shehata, MA; Gauger, SJ; Veronesi, C; Hamborg, L; Thiesen, L; Bruus-Jensen, J; Royssen, JS; Leurs, U; Larsen, ASG; Krall, J; Solbak, SMØ; Wellendorph, P; Frølund, B Exploring the NCS-382 Scaffold for CaMKII? Modulation: Synthesis, Biochemical Pharmacology, and Biophysical Characterization of Ph-HTBA as a Novel High-Affinity Brain-Penetrant Stabilizer of the CaMKII? Hub Domain. J Med Chem 65:15066-15084 (2022) [PubMed] 
Target
Name:
Calcium/calmodulin-dependent protein kinase type II subunit alpha
Synonyms:
CAMK2A | CAMKA | CaM kinase II | CaM kinase II alpha | Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMK2a) | KCC2A_HUMAN | KIAA0968
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54093.63
Organism:
Homo sapiens (Human)
Description:
gi_25952118
Residue:
478
Sequence:
MATITCTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSGGKSGGNKKSDGVKESSESTNTTIEDEDTKVRKQEIIKVTEQLIEAISNGDFESYTKMCDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIHLMGDESACIAYIRITQYLDAGGIPRTAQSEETRVWHRRDGKWQIVHFHRSGAPSVLPH
  
Inhibitor
Name:
BDBM50228744
Synonyms:
5-Hydroxy-Diclofenac | CHEBI:59612
Type:
Small organic molecule
Emp. Form.:
C14H11Cl2NO3
Mol. Mass.:
312.148
SMILES:
OC(=O)Cc1cc(O)ccc1Nc1c(Cl)cccc1Cl
Structure:
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