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Target
Methionine aminopeptidase 1
Ligand
BDBM50160045
Substrate
n/a
Meas. Tech.
ChEMBL_305881 (CHEMBL832744)
IC50
62860.0±n/a nM
Citation
 Luo, QL; Li, JY; Liu, ZY; Chen, LL; Li, J; Ye, QZ; Nan, FJ Inhibitors of type I MetAPs containing pyridine-2-carboxylic acid thiazol-2-ylamide. Part 1: SAR studies on the determination of the key scaffold. Bioorg Med Chem Lett 15:635-8 (2005) [PubMed]  Article 
Target
Name:
Methionine aminopeptidase 1
Synonyms:
MAP 1 | MAP1 | MAP1_YEAST | MetAP 1 | Peptidase M 1
Type:
PROTEIN
Mol. Mass.:
43382.92
Organism:
Saccharomyces cerevisiae
Description:
ChEMBL_10701
Residue:
387
Sequence:
MSTATTTVTTSDQASHPTKIYCSGLQCGRETSSQMKCPVCLKQGIVSIFCDTSCYENNYKAHKALHNAKDGLEGAYDPFPKFKYSGKVKASYPLTPRRYVPEDIPKPDWAANGLPVSEQRNDRLNNIPIYKKDQIKKIRKACMLGREVLDIAAAHVRPGITTDELDEIVHNETIKRGAYPSPLNYYNFPKSLCTSVNEVICHGVPDKTVLKEGDIVNLDVSLYYQGYHADLNETYYVGENISKEALNTTETSRECLKLAIKMCKPGTTFQELGDHIEKHATENKCSVVRTYCGHGVGEFFHCSPNIPHYAKNRTPGVMKPGMVFTIEPMINEGTWKDMTWPDDWTSTTQDGKLSAQFEHTLLVTEHGVEILTARNKKSPGGPRQRIK
  
Inhibitor
Name:
BDBM50160045
Synonyms:
CHEMBL179906 | [6-(Thiazol-2-ylcarbamoyl)-pyridin-3-yl]-carbamic acid tert-butyl ester
Type:
Small organic molecule
Emp. Form.:
C14H16N4O3S
Mol. Mass.:
320.367
SMILES:
CC(C)(C)OC(=O)Nc1ccc(nc1)C(=O)Nc1nccs1
Structure:
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