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Target
Methionine aminopeptidase
Ligand
BDBM50129661
Substrate
n/a
Meas. Tech.
ChEMBL_305626 (CHEMBL828659)
IC50
5000±n/a nM
Citation
 Luo, QL; Li, JY; Liu, ZY; Chen, LL; Li, J; Ye, QZ; Nan, FJ Inhibitors of type I MetAPs containing pyridine-2-carboxylic acid thiazol-2-ylamide. Part 1: SAR studies on the determination of the key scaffold. Bioorg Med Chem Lett 15:635-8 (2005) [PubMed]  Article 
Target
Name:
Methionine aminopeptidase
Synonyms:
EcMetAP | MAP1_ECOLI | Methionine Aminopeptidase (MAP) | Methionine aminopeptidase | Peptidase M | map
Type:
Enzyme
Mol. Mass.:
29326.96
Organism:
Escherichia coli (strain K12)
Description:
Full-length untagged EcMAP was expressed in E. coli.
Residue:
264
Sequence:
MAISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHDE
  
Inhibitor
Name:
BDBM50129661
Synonyms:
CHEMBL89671 | N-(thiazol-2-yl)picolinamide | Pyridine-2-carboxylic acid thiazol-2-ylamide
Type:
Small organic molecule
Emp. Form.:
C9H7N3OS
Mol. Mass.:
205.236
SMILES:
O=C(Nc1nccs1)c1ccccn1
Structure:
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