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Target
RNA-directed RNA polymerase
Ligand
BDBM50160232
Substrate
n/a
Meas. Tech.
ChEMBL_306597 (CHEMBL832944)
IC50
30000±n/a nM
Citation
 Ding, Y; Girardet, JL; Smith, KL; Larson, G; Prigaro, B; Lai, VC; Zhong, W; Wu, JZ Parallel synthesis of pteridine derivatives as potent inhibitors for hepatitis C virus NS5B RNA-dependent RNA polymerase. Bioorg Med Chem Lett 15:675-8 (2005) [PubMed]  Article 
Target
Name:
RNA-directed RNA polymerase
Synonyms:
Hepatitis C virus NS5B RNA-dependent RNA polymerase | NS5B protein
Type:
Protein
Mol. Mass.:
25173.95
Organism:
Hepatitis C virus
Description:
Q8JXU8
Residue:
229
Sequence:
RTEEAIYQCCDLDPQARVAIRSLTERLYVGGPLTNSRGENCGYRRRASGVLTTSCGNTLTCYIKAQAACRAAGRQDCTMLVCGDDLVVICESAGVQEDAASLRAFTEAMTRYSAPPGDPPQPEYDLELITSCSSNVSVAHDGAGKRVYYLTRDPTTPLARAAWETARHTPVNSWLGNIIMFAPTLWVRMIMLTHFFSVLIARDQLEQALDCEIYGACYSIEPLLPPIIQ
  
Inhibitor
Name:
BDBM50160232
Synonyms:
7-(4-Nitro-phenyl)-6-phenyl-pteridin-4-ol | CHEMBL181908
Type:
Small organic molecule
Emp. Form.:
C18H11N5O3
Mol. Mass.:
345.3116
SMILES:
[O-][N+](=O)c1ccc(cc1)-c1nc2nc[n-]c(=[OH+])c2nc1-c1ccccc1
Structure:
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