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Target
DNA polymerase III subunit alpha
Ligand
BDBM50160349
Substrate
n/a
Meas. Tech.
ChEMBL_302895 (CHEMBL830211)
Ki
>280000±n/a nM
Citation
 Wright, GE; Brown, NC; Xu, WC; Long, ZY; Zhi, C; Gambino, JJ; Barnes, MH; Butler, MM Active site directed inhibitors of replication-specific bacterial DNA polymerases. Bioorg Med Chem Lett 15:729-32 (2005) [PubMed]  Article 
Target
Name:
DNA polymerase III subunit alpha
Synonyms:
DNA polymerase III dnaE | DNA polymerase III subunit alpha | DNA polymerase IIIE | DPO3A_ECOLI | dnaE | polC
Type:
Enzyme
Mol. Mass.:
129872.84
Organism:
Escherichia coli
Description:
Enzyme was purified from recombinant strains.
Residue:
1160
Sequence:
MSEPRFVHLRVHSDYSMIDGLAKTAPLVKKAAALGMPALAITDFTNLCGLVKFYGAGHGAGIKPIVGADFNVQCDLLGDELTHLTVLAANNTGYQNLTLLISKAYQRGYGAAGPIIDRDWLIELNEGLILLSGGRMGDVGRSLLRGNSALVDECVAFYEEHFPDRYFLELIRTGRPDEESYLHAAVELAEARGLPVVATNDVRFIDSSDFDAHEIRVAIHDGFTLDDPKRPRNYSPQQYMRSEEEMCELFADIPEALANTVEIAKRCNVTVRLGEYFLPQFPTGDMSTEDYLVKRAKEGLEERLAFLFPDEEERLKRRPEYDERLETELQVINQMGFPGYFLIVMEFIQWSKDNGVPVGPGRGSGAGSLVAYALKITDLDPLEFDLLFERFLNPERVSMPDFDVDFCMEKRDQVIEHVADMYGRDAVSQIITFGTMAAKAVIRDVGRVLGHPYGFVDRISKLIPPDPGMTLAKAFEAEPQLPEIYEADEEVKALIDMARKLEGVTRNAGKHAGGVVIAPTKITDFAPLYCDEEGKHPVTQFDKSDVEYAGLVKFDFLGLRTLTIINWALEMINKRRAKNGEPPLDIAAIPLDDKKSFDMLQRSETTAVFQLESRGMKDLIKRLQPDCFEDMIALVALFRPGPLQSGMVDNFIDRKHGREEISYPDVQWQHESLKPVLEPTYGIILYQEQVMQIAQVLSGYTLGGADMLRRAMGKKKPEEMAKQRSVFAEGAEKNGINAELAMKIFDLVEKFAGYGFNKSHSAAYALVSYQTLWLKAHYPAEFMAAVMTADMDNTEKVVGLVDECWRMGLKILPPDINSGLYHFHVNDDGEIVYGIGAIKGVGEGPIEAIIEARNKGGYFRELFDLCARTDTKKLNRRVLEKLIMSGAFDRLGPHRAALMNSLGDALKAADQHAKAEAIGQADMFGVLAEEPEQIEQSYASCQPWPEQVVLDGERETLGLYLTGHPINQYLKEIERYVGGVRLKDMHPTERGKVITAAGLVVAARVMVTKRGNRIGICTLDDRSGRLEVMLFTDALDKYQQLLEKDRILIVSGQVSFDDFSGGLKMTAREVMDIDEAREKYARGLAISLTDRQIDDQLLNRLRQSLEPHRSGTIPVHLYYQRADARARLRFGATWRVSPSDRLLNDLRGLIGSEQVELEFD
  
Inhibitor
Name:
BDBM50160349
Synonyms:
6-(4-Chloro-3-chloromethyl-benzylamino)-1H-pyrimidine-2,4-dione | CHEMBL435556
Type:
Small organic molecule
Emp. Form.:
C12H11Cl2N3O2
Mol. Mass.:
300.141
SMILES:
ClCc1cc(CNc2cc(=O)[nH]c(=O)[nH]2)ccc1Cl
Structure:
Search PDB for entries with ligand similarity: