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Target
Aspartate aminotransferase, cytoplasmic
Ligand
BDBM50462552
Substrate
n/a
Meas. Tech.
ChEMBL_2193290 (CHEMBL5105650)
IC50
84600±n/a nM
Citation
 Wu, Q; Sun, Z; Chen, Z; Liu, J; Ding, H; Luo, C; Wang, M; Du, D The discovery of a non-competitive GOT1 inhibitor, hydralazine hydrochloride, via a coupling reaction-based high-throughput screening assay. Bioorg Med Chem Lett 73:0 (2022) [PubMed] 
Target
Name:
Aspartate aminotransferase, cytoplasmic
Synonyms:
2.6.1.1 | 2.6.1.3 | AATC_HUMAN | Aspartate aminotransferase, cytoplasmic | Cysteine aminotransferase, cytoplasmic | Cysteine transaminase, cytoplasmic | GOT1 | Glutamate oxaloacetate transaminase 1 | Transaminase A | cAspAT | cCAT
Type:
PROTEIN
Mol. Mass.:
46249.45
Organism:
Homo sapiens
Description:
ChEMBL_105469
Residue:
413
Sequence:
MAPPSVFAEVPQAQPVLVFKLTADFREDPDPRKVNLGVGAYRTDDCHPWVLPVVKKVEQKIANDNSLNHEYLPILGLAEFRSCASRLALGDDSPALKEKRVGGVQSLGGTGALRIGADFLARWYNGTNNKNTPVYVSSPTWENHNAVFSAAGFKDIRSYRYWDAEKRGLDLQGFLNDLENAPEFSIVVLHACAHNPTGIDPTPEQWKQIASVMKHRFLFPFFDSAYQGFASGNLERDAWAIRYFVSEGFEFFCAQSFSKNFGLYNERVGNLTVVGKEPESILQVLSQMEKIVRITWSNPPAQGARIVASTLSNPELFEEWTGNVKTMADRILTMRSELRARLEALKTPGTWNHITDQIGMFSFTGLNPKQVEYLVNEKHIYLLPSGRINVSGLTTKNLDYVATSIHEAVTKIQ
  
Inhibitor
Name:
BDBM50462552
Synonyms:
CHEMBL4237925
Type:
Small organic molecule
Emp. Form.:
C19H20N4O
Mol. Mass.:
320.3883
SMILES:
O=C(Nc1ccccc1)N1CCN(CC1)c1cccc2[nH]ccc12
Structure:
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