Reaction Details Report a problem with these data
Target
Aurora kinase B-B
Ligand
BDBM142744
Substrate
n/a
Meas. Tech.
ChEMBL_2193470 (CHEMBL5105830)
IC50
3.0±n/a nM
Citation
 Wang, H; Chi, L; Yu, F; Dai, H; Si, X; Gao, C; Wang, Z; Liu, L; Zheng, J; Ke, Y; Liu, H; Zhang, Q The overview of Mitogen-activated extracellular signal-regulated kinase (MEK)-based dual inhibitor in the treatment of cancers. Bioorg Med Chem 70:0 (2022) [PubMed] 
Target
Name:
Aurora kinase B-B
Synonyms:
AUKBB_XENLA | Aurora kinase B | airk2-b | aurkb-b
Type:
Protein
Mol. Mass.:
42037.56
Organism:
Xenopus laevis (African clawed frog)
Description:
Q6GPL3
Residue:
368
Sequence:
MSYKENLIPSSCSSSSSSSSKFATPSSATAAQRVLRKQPYVSIFTTPSDNLLAQRAQLAPRVTPAASSSVPGRVALGTDVASHNTALAEAPKRKFTIDDFDIGRPLGKGKFGNVYLAREKQNKFIMALKVLFKSQLEKEGVEHQLRREIEIQSHLRHPNILRMYNYFHDRKRIYLMLEFAPRGELYKELQKHGRFDEQRSATFMEELADALQYCHERKVIHRDIKPENLLMGYKGELKIADFGWSVHAPSLRRRTMCGTLDYLPPEMIEGKTHDEKVDLWCAGVLCYEFLVGMPPFDSPSHSETHRRIVNVDLKFPPFLSEGSKDLISKLLRYHPAQRLPLKGVMEHPWVKANSRRVLPPVYQSSHPK
  
Inhibitor
Name:
BDBM142744
Synonyms:
US8937095, 6
Type:
Small organic molecule
Emp. Form.:
C29H28N4O2
Mol. Mass.:
464.5582
SMILES:
CCNC(=O)C#Cc1ccc2\C(=C(\Nc3ccc(CN(C)C)cc3)c3ccccc3)C(=O)Nc2c1
Structure:
Search PDB for entries with ligand similarity: