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Target
SRSF protein kinase 2
Ligand
BDBM50512854
Substrate
n/a
Meas. Tech.
ChEMBL_2193530 (CHEMBL5105890)
IC50
98±n/a nM
Citation
 Tang, J; Xie, Y; Huang, J; Zhang, L; Jiang, W; Li, Z; Bian, J A critical update on the strategies towards small molecule inhibitors targeting Serine/arginine-rich (SR) proteins and Serine/arginine-rich proteins related kinases in alternative splicing. Bioorg Med Chem 70:0 (2022) [PubMed] 
Target
Name:
SRSF protein kinase 2
Synonyms:
SFRS protein kinase 2 | SR-protein-specific kinase 2 | SRPK2 | SRPK2_HUMAN | SRSF protein kinase 2 | SRSF protein kinase 2 C-terminal | SRSF protein kinase 2 N-terminal | Serine/arginine-rich protein-specific kinase 2 | Serine/threonine-protein kinase SRPK2
Type:
PROTEIN
Mol. Mass.:
77488.98
Organism:
Homo sapiens (Human)
Description:
ChEMBL_774248
Residue:
688
Sequence:
MSVNSEKSSSSERPEPQQKAPLVPPPPPPPPPPPPPLPDPTPPEPEEEILGSDDEEQEDPADYCKGGYHPVKIGDLFNGRYHVIRKLGWGHFSTVWLCWDMQGKRFVAMKVVKSAQHYTETALDEIKLLKCVRESDPSDPNKDMVVQLIDDFKISGMNGIHVCMVFEVLGHHLLKWIIKSNYQGLPVRCVKSIIRQVLQGLDYLHSKCKIIHTDIKPENILMCVDDAYVRRMAAEATEWQKAGAPPPSGSAVSTAPQQKPIGKISKNKKKKLKKKQKRQAELLEKRLQEIEELEREAERKIIEENITSAAPSNDQDGEYCPEVKLKTTGLEEAAEAETAKDNGEAEDQEEKEDAEKENIEKDEDDVDQELANIDPTWIESPKTNGHIENGPFSLEQQLDDEDDDEEDCPNPEEYNLDEPNAESDYTYSSSYEQFNGELPNGRHKIPESQFPEFSTSLFSGSLEPVACGSVLSEGSPLTEQEESSPSHDRSRTVSASSTGDLPKAKTRAADLLVNPLDPRNADKIRVKIADLGNACWVHKHFTEDIQTRQYRSIEVLIGAGYSTPADIWSTACMAFELATGDYLFEPHSGEDYSRDEDHIAHIIELLGSIPRHFALSGKYSREFFNRRGELRHITKLKPWSLFDVLVEKYGWPHEDAAQFTDFLIPMLEMVPEKRASAGECLRHPWLNS
  
Inhibitor
Name:
BDBM50512854
Synonyms:
CHEMBL4468747 | US11066363, Compound 37
Type:
Small organic molecule
Emp. Form.:
C27H21FN2O3S
Mol. Mass.:
472.531
SMILES:
CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1-c1cccc(c1)S(F)(=O)=O
Structure:
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