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Target
Dual specificity protein kinase CLK4
Ligand
BDBM293424
Substrate
n/a
Meas. Tech.
ChEMBL_2193622 (CHEMBL5105982)
IC50
1.000000±n/a nM
Citation
 Blackie, AC; Foley, DJ Exploring the roles of the Cdc2-like kinases in cancers. Bioorg Med Chem 70:0 (2022) [PubMed] 
Target
Name:
Dual specificity protein kinase CLK4
Synonyms:
CDC-like kinase 4 | CLK4 | CLK4_HUMAN | Dual specificity protein kinase CLK1/CLK4
Type:
Serine/threonine-protein kinase
Mol. Mass.:
57522.53
Organism:
Homo sapiens (Human)
Description:
gi_10190706
Residue:
481
Sequence:
MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK
  
Inhibitor
Name:
BDBM293424
Synonyms:
US10106527, Compound 10 | US10106527, Compound 142 | US10106527, Compound 143 | US10106527, Compound 144 | US10106527, Compound 459 | US10544128, Compound 144 | US11548872, Compound 459 | US20230286945, Compound 459 | US9951048, Compound 459
Type:
Small organic molecule
Emp. Form.:
C24H25N7O
Mol. Mass.:
427.5016
SMILES:
CN1CCN(CC1)c1cc(ccn1)C(=O)Nc1cc2cc(ccc2cn1)-c1cnn(C)c1
Structure:
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