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Target
Dual specificity protein kinase CLK4
Ligand
BDBM50589476
Substrate
n/a
Meas. Tech.
ChEMBL_2193642 (CHEMBL5106002)
IC50
14±n/a nM
Citation
 Blackie, AC; Foley, DJ Exploring the roles of the Cdc2-like kinases in cancers. Bioorg Med Chem 70:0 (2022) [PubMed] 
Target
Name:
Dual specificity protein kinase CLK4
Synonyms:
CDC-like kinase 4 | CLK4 | CLK4_HUMAN | Dual specificity protein kinase CLK1/CLK4
Type:
Serine/threonine-protein kinase
Mol. Mass.:
57522.53
Organism:
Homo sapiens (Human)
Description:
gi_10190706
Residue:
481
Sequence:
MRHSKRTHCPDWDSRESWGHESYRGSHKRKRRSHSSTQENRHCKPHHQFKESDCHYLEARSLNERDYRDRRYVDEYRNDYCEGYVPRHYHRDIESGYRIHCSKSSVRSRRSSPKRKRNRHCSSHQSRSKSHRRKRSRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAVKIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKENSFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTDIKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSKEHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAGRYVRRRCKPLKEFMLCHDEEHEKLFDLVRRMLEYDPTQRITLDEALQHPFFDLLKKK
  
Inhibitor
Name:
BDBM50589476
Synonyms:
CHEMBL5185809
Type:
Small organic molecule
Emp. Form.:
C17H13N5OS
Mol. Mass.:
335.383
SMILES:
O=C(Nc1ccc2[nH]cnc2c1)c1csc(Nc2ccccc2)n1
Structure:
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