Target
Collagenase 3
Ligand
BDBM50160857
Substrate
n/a
Meas. Tech.
ChEMBL_302508 (CHEMBL828223)
Ki
2200±n/a nM
Citation
 Kim, SHPudzianowski, ATLeavitt, KJBarbosa, JMcDonnell, PAMetzler, WJRankin, BMLiu, RVaccaro, WPitts, W Structure-based design of potent and selective inhibitors of collagenase-3 (MMP-13). Bioorg Med Chem Lett 15:1101-6 (2005) [PubMed]  Article 
Target
Name:
Collagenase 3
Synonyms:
MMP-13 | MMP13 | MMP13_HUMAN | Matrix metalloproteinase-13 | Matrix metalloproteinase-13 (MMP-13) | Matrix metalloproteinase-13 (MMP13)
Type:
Enzyme
Mol. Mass.:
53808.06
Organism:
Homo sapiens (Human)
Description:
P45452
Residue:
471
Sequence:
MHPGVLAAFLFLSWTHCRALPLPSGGDEDDLSEEDLQFAERYLRSYYHPTNLAGILKENAASSMTERLREMQSFFGLEVTGKLDDNTLDVMKKPRCGVPDVGEYNVFPRTLKWSKMNLTYRIVNYTPDMTHSEVEKAFKKAFKVWSDVTPLNFTRLHDGIADIMISFGIKEHGDFYPFDGPSGLLAHAFPPGPNYGGDAHFDDDETWTSSSKGYNLFLVAAHEFGHSLGLDHSKDPGALMFPIYTYTGKSHFMLPDDDVQGIQSLYGPGDEDPNPKHPKTPDKCDPSLSLDAITSLRGETMIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGYDILEGYPKKISELGLPKEVKKISAAVHFEDTGKTLLFSGNQVWRYDDTNHIMDKDYPRLIEEDFPGIGDKVDAVYEKNGYIYFFNGPIQFEYSIWSNRIVRVMPANSILWC
  
Inhibitor
Name:
BDBM50160857
Synonyms:
1-Phenyl-1,7,9-triaza-spiro[4.5]decane-2,6,8,10-tetraone | CHEMBL178651
Type:
Small organic molecule
Emp. Form.:
C13H11N3O4
Mol. Mass.:
273.2441
SMILES:
O=C1CCC2(N1c1ccccc1)C(=O)NC(=O)NC2=O
Structure:
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