Reaction Details Report a problem with these data
Target
Growth factor receptor-bound protein 2
Ligand
BDBM50161189
Substrate
n/a
Meas. Tech.
ChEMBL_302172 (CHEMBL829239)
Kd
0.097±n/a nM
Citation
 Oishi, S; Karki, RG; Kang, SU; Wang, X; Worthy, KM; Bindu, LK; Nicklaus, MC; Fisher, RJ; Burke, TR Design and synthesis of conformationally constrained Grb2 SH2 domain binding peptides employing alpha-methylphenylalanyl based phosphotyrosyl mimetics. J Med Chem 48:764-72 (2005) [PubMed]  Article 
Target
Name:
Growth factor receptor-bound protein 2
Synonyms:
ASH | GRB2 | GRB2 adapter protein | GRB2_HUMAN | Grb2-SH2 | Growth factor receptor-bound protein 2
Type:
Protein
Mol. Mass.:
25205.04
Organism:
Homo sapiens (Human)
Description:
P62993
Residue:
217
Sequence:
MEAIAKYDFKATADDELSFKRGDILKVLNEECDQNWYKAELNGKDGFIPKNYIEMKPHPWFFGKIPRAKAEEMLSKQRHDGAFLIRESESAPGDFSLSVKFGNDVQHFKVLRDGAGKYFLWVVKFNSLNELVDYHRSTSVSRNQQIFLRDIEQVPQQPTYVQALFDFDPQEDGELGFRRGDFIHVMDNSDPNWWKGACHGQTGMFPRNYVTPVNRNV
  
Inhibitor
Name:
BDBM50161189
Synonyms:
(S)-4-{5-[(S)-2-Carbamoyl-1-(3-naphthalen-1-yl-propylcarbamoyl)-ethylcarbamoyl]-pentylcarbamoyl}-5-[4-(1-phosphono-ethyl)-phenyl]-pentanoic acid | CHEMBL175456
Type:
Small organic molecule
Emp. Form.:
C40H46N4O10P2
Mol. Mass.:
804.7616
SMILES:
C[C@@]1(Cc2ccc(cc2)P(O)(O)=O)NC(=O)CC(\C=C\C[C@@H](Cc2cccc3ccccc23)CNC(=O)[C@H](CC(N)=O)NC1=O)c1ccc(CP(O)(O)=O)cc1 |t:19|
Structure:
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