Reaction Details Report a problem with these data
Target
Phospholipase A2, membrane associated
Ligand
BDBM50161293
Substrate
n/a
Meas. Tech.
ChEMBL_306495 (CHEMBL828100)
IC50
6±n/a nM
Citation
 Sawyer, JS; Beight, DW; Smith, EC; Snyder, DW; Chastain, MK; Tielking, RL; Hartley, LW; Carlson, DG Carbocyclic[g]indole inhibitors of human nonpancreatic s-PLA2. J Med Chem 48:893-6 (2005) [PubMed]  Article 
Target
Name:
Phospholipase A2, membrane associated
Synonyms:
GIIC sPLA2 | Group IIA phospholipase A2 | NPS-PLA2 | Non-Pancreatic Secretory Phospholipase A2 | Non-pancreatic secretory phospholipase A2 (hnps-PLA2) | PA2GA_HUMAN | PLA2B | PLA2G2A | PLA2L | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2 group IIA | RASF-A
Type:
Hydrolase
Mol. Mass.:
16101.20
Organism:
Homo sapiens (Human)
Description:
The human nps PLA2 was cloned, and expressed in E. coli. There was a refolding process in the purification.
Residue:
144
Sequence:
MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC
  
Inhibitor
Name:
BDBM50161293
Synonyms:
(3-Aminooxalyl-1-benzyl-2-methyl-1,6,7,8-tetrahydro-1-aza-as-indacen-4-yloxy)-acetic acid | CHEMBL361552
Type:
Small organic molecule
Emp. Form.:
C23H22N2O5
Mol. Mass.:
406.4312
SMILES:
Cc1c(C(=O)C(N)=O)c2c(OCC(O)=O)cc3CCCc3c2n1Cc1ccccc1
Structure:
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