Reaction Details Report a problem with these data
Target
Phospholipase A2, membrane associated
Ligand
BDBM50161301
Substrate
n/a
Meas. Tech.
ChEMBL_306495 (CHEMBL828100)
IC50
3±n/a nM
Citation
 Sawyer, JS; Beight, DW; Smith, EC; Snyder, DW; Chastain, MK; Tielking, RL; Hartley, LW; Carlson, DG Carbocyclic[g]indole inhibitors of human nonpancreatic s-PLA2. J Med Chem 48:893-6 (2005) [PubMed]  Article 
Target
Name:
Phospholipase A2, membrane associated
Synonyms:
GIIC sPLA2 | Group IIA phospholipase A2 | NPS-PLA2 | Non-Pancreatic Secretory Phospholipase A2 | Non-pancreatic secretory phospholipase A2 (hnps-PLA2) | PA2GA_HUMAN | PLA2B | PLA2G2A | PLA2L | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2 group IIA | RASF-A
Type:
Hydrolase
Mol. Mass.:
16101.20
Organism:
Homo sapiens (Human)
Description:
The human nps PLA2 was cloned, and expressed in E. coli. There was a refolding process in the purification.
Residue:
144
Sequence:
MKTLLLLAVIMIFGLLQAHGNLVNFHRMIKLTTGKEAALSYGFYGCHCGVGGRGSPKDATDRCCVTHDCCYKRLEKRGCGTKFLSYKFSNSGSRITCAKQDSCRSQLCECDKAAATCFARNKTTYNKKYQYYSNKHCRGSTPRC
  
Inhibitor
Name:
BDBM50161301
Synonyms:
2-[4-(2-Benzenesulfonylamino-2-oxo-ethoxy)-1-benzyl-2-methyl-6,7,8,9-tetrahydro-1H-benzo[g]indol-3-yl]-2-oxo-acetamide | CHEMBL180576
Type:
Small organic molecule
Emp. Form.:
C30H29N3O6S
Mol. Mass.:
559.633
SMILES:
Cc1c(C(=O)C(N)=O)c2c(OCC(=O)NS(=O)(=O)c3ccccc3)cc3CCCCc3c2n1Cc1ccccc1
Structure:
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