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Target
Gonadotropin-releasing hormone receptor
Ligand
BDBM50161503
Substrate
n/a
Meas. Tech.
ChEMBL_303063 (CHEMBL828889)
Ki
220±n/a nM
Citation
 Pontillo, J; Chen, C Efficient synthesis of bicyclic oxazolino- and thiazolino[3,2-c]pyrimidine-5,7-diones and its application to the synthesis of GnRH antagonists. Bioorg Med Chem Lett 15:1407-11 (2005) [PubMed]  Article 
Target
Name:
Gonadotropin-releasing hormone receptor
Synonyms:
GNRHR | GNRHR_HUMAN | GRHR | GnRH receptor | GnRH-R | Gonadotropin releasing hormone 1 (GnRHR1) | Gonadotropin-releasing hormone receptor | Gonadotropin-releasing hormone receptor (GnRH)
Type:
Enzyme
Mol. Mass.:
37749.45
Organism:
Homo sapiens (Human)
Description:
P30968
Residue:
328
Sequence:
MANSASPEQNQNHCSAINNSIPLMQGNLPTLTLSGKIRVTVTFFLFLLSATFNASFLLKLQKWTQKKEKGKKLSRMKLLLKHLTLANLLETLIVMPLDGMWNITVQWYAGELLCKVLSYLKLFSMYAPAFMMVVISLDRSLAITRPLALKSNSKVGQSMVGLAWILSSVFAGPQLYIFRMIHLADSSGQTKVFSQCVTHCSFSQWWHQAFYNFFTFSCLFIIPLFIMLICNAKIIFTLTRVLHQDPHELQLNQSKNNIPRARLKTLKMTVAFATSFTVCWTPYYVLGIWYWFDPEMLNRLSDPVNHFFFLFAFLNPCFDPLIYGYFSL
  
Inhibitor
Name:
BDBM50161503
Synonyms:
6-(2-Amino-2-phenyl-ethyl)-3,8-bis-(2-fluoro-phenyl)-2,3-dihydro-thiazolo[3,2-c]pyrimidine-5,7-dione | CHEMBL362283
Type:
Small organic molecule
Emp. Form.:
C26H21F2N3O2S
Mol. Mass.:
477.526
SMILES:
NC(Cn1c(=O)c(c2SCC(c3ccccc3F)n2c1=O)-c1ccccc1F)c1ccccc1 |(-3.05,-.44,;-3.05,1.1,;-1.72,1.87,;-.37,1.1,;.94,1.88,;.94,3.42,;2.27,1.1,;2.27,-.44,;3.41,-1.45,;2.78,-2.83,;1.27,-2.68,;.24,-3.83,;-1.28,-3.5,;-2.3,-4.63,;-1.84,-6.1,;-.32,-6.42,;.71,-5.28,;2.22,-5.6,;.96,-1.19,;-.37,-.44,;-1.72,-1.21,;3.62,1.87,;4.93,1.1,;6.28,1.86,;6.28,3.4,;4.93,4.19,;3.6,3.41,;2.27,4.17,;-4.38,1.87,;-5.71,1.09,;-7.04,1.84,;-7.04,3.4,;-5.71,4.17,;-4.38,3.41,)|
Structure:
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