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Target
Beta-galactoside alpha-2,6-sialyltransferase 1
Ligand
BDBM50590206
Substrate
n/a
Meas. Tech.
ChEMBL_2195616 (CHEMBL5108132)
Ki
19±n/a nM
Citation
 Dobie, C; Montgomery, AP; Szabo, R; Yu, H; Skropeta, D Synthesis and biological evaluation of selective phosphonate-bearing 1,2,3-triazole-linked sialyltransferase inhibitors. RSC Med Chem 12:1680-1689 (2021) [PubMed] 
Target
Name:
Beta-galactoside alpha-2,6-sialyltransferase 1
Synonyms:
Alpha 2,6-ST 1 | B-cell antigen CD75 | Beta-galactoside alpha-2,6-sialyltransferase 1 | CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase 1 | SIAT1 | SIAT1_HUMAN | ST6GAL1 | ST6Gal I | ST6GalI | Sialyltransferase 1
Type:
PROTEIN
Mol. Mass.:
46622.19
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109837
Residue:
406
Sequence:
MIHTNLKKKFSCCVLVFLLFAVICVWKEKKKGSYYDSFKLQTKEFQVLKSLGKLAMGSDSQSVSSSSTQDPHRGRQTLGSLRGLAKAKPEASFQVWNKDSSSKNLIPRLQKIWKNYLSMNKYKVSYKGPGPGIKFSAEALRCHLRDHVNVSMVEVTDFPFNTSEWEGYLPKESIRTKAGPWGRCAVVSSAGSLKSSQLGREIDDHDAVLRFNGAPTANFQQDVGTKTTIRLMNSQLVTTEKRFLKDSLYNEGILIVWDPSVYHSDIPKWYQNPDYNFFNNYKTYRKLHPNQPFYILKPQMPWELWDILQEISPEEIQPNPPSSGMLGIIIMMTLCDQVDIYEFLPSKRKTDVCYYYQKFFDSACTMGAYHPLLYEKNLVKHLNQGTDEDIYLLGKATLPGFRTIHC
  
Inhibitor
Name:
BDBM50590206
Synonyms:
CHEMBL4117853
Type:
Small organic molecule
Emp. Form.:
C22H25N3O12P2
Mol. Mass.:
585.3943
SMILES:
Nc1ccn([C@@H]2O[C@H](COP(O)(=O)O[C@@H](c3cccc(Oc4ccccc4)c3)P(O)(O)=O)[C@@H](O)[C@H]2O)c(=O)n1 |r|
Structure:
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