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Target
Elongin-C
Ligand
BDBM50459881
Substrate
n/a
Meas. Tech.
ChEMBL_2195888 (CHEMBL5108404)
IC50
1136±n/a nM
Citation
 de Castro, GV; Ciulli, A Estimating the cooperativity of PROTAC-induced ternary complexes using  RSC Med Chem 12:1765-1770 (2021) [PubMed] 
Target
Name:
Elongin-C
Synonyms:
ELOC | ELOC_HUMAN | Elongin 15 kDa subunit | Elongin-C | RNA polymerase II transcription factor SIII subunit C | SIII p15 | TCEB1 | Transcription elongation factor B polypeptide 1
Type:
PROTEIN
Mol. Mass.:
12466.49
Organism:
Homo sapiens (Human)
Description:
ChEMBL_108414
Residue:
112
Sequence:
MDGEEKTYGGCEGPDAMYVKLISSDGHEFIVKREHALTSGTIKAMLSGPGQFAENETNEVNFREIPSHVLSKVCMYFTYKVRYTNSSTEIPEFPIAPEIALELLMAANFLDC
  
Inhibitor
Name:
BDBM50459881
Synonyms:
CHEMBL4226376
Type:
Small organic molecule
Emp. Form.:
C57H70ClN7O10S
Mol. Mass.:
1080.725
SMILES:
C[C@H]1C[C@@H](Nc2ccc(Cl)cc2)c2cc(ccc2N1C(C)=O)-c1ccc(cc1)C(=O)NCCOCCOCCOCCOCC(=O)N[C@H](C(=O)N1C[C@H](O)C[C@H]1C(=O)NCc1ccc(cc1)-c1scnc1C)C(C)(C)C |r|
Structure:
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