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Target
Ubiquitin carboxyl-terminal hydrolase isozyme L3
Ligand
BDBM50590283
Substrate
n/a
Meas. Tech.
ChEMBL_2195896 (CHEMBL5108412)
IC50
>10.0±n/a nM
Citation
 Panyain, N; Godinat, A; Thawani, AR; Lachiondo-Ortega, S; Mason, K; Elkhalifa, S; Smith, LM; Harrigan, JA; Tate, EW Activity-based protein profiling reveals deubiquitinase and aldehyde dehydrogenase targets of a cyanopyrrolidine probe. RSC Med Chem 12:1935-1943 (2021) [PubMed] 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase isozyme L3
Synonyms:
UCHL3 | UCHL3_HUMAN | Ubiquitin C-terminal Hydrolase L3 (UCH-L3) | Ubiquitin thioesterase L3
Type:
Hydrolase; protease
Mol. Mass.:
26168.69
Organism:
Homo sapiens (Human)
Description:
Human recombinant UCH-L3 was purchased from Boston Biochem, Inc.(Cambridge, MA).
Residue:
230
Sequence:
MEGQRWLPLEANPEVTNQFLKQLGLHPNWQFVDVYGMDPELLSMVPRPVCAVLLLFPITEKYEVFRTEEEEKIKSQGQDVTSSVYFMKQTISNACGTIGLIHAIANNKDKMHFESGSTLKKFLEESVSMSPEERARYLENYDAIRVTHETSAHEGQTEAPSIDEKVDLHFIALVHVDGHLYELDGRKPFPINHGETSDETLLEDAIEVCKKFMERDPDELRFNAIALSAA
  
Inhibitor
Name:
BDBM50590283
Synonyms:
CHEMBL5169766 | US20230303547, Reference Example D
Type:
Small organic molecule
Emp. Form.:
C15H14N4OS
Mol. Mass.:
298.363
SMILES:
O=C(Nc1ncc(s1)-c1ccccc1)[C@H]1CCN(C1)C#N |r|
Structure:
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