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Target
Bcl-2-like protein 1
Ligand
BDBM156378
Substrate
n/a
Meas. Tech.
ChEMBL_2196200 (CHEMBL5108716)
IC50
4.5±n/a nM
Citation
 Zhang, Z; Bai, L; Hou, L; Deng, H; Luan, S; Liu, D; Huang, M; Zhao, L Trends in targeting Bcl-2 anti-apoptotic proteins for cancer treatment. Eur J Med Chem 232:0 (2022) [PubMed] 
Target
Name:
Bcl-2-like protein 1
Synonyms:
Anti-apoptotic Bcl-2 protein | Apoptosis Regulator Bcl-xL | Apoptosis regulator Bcl-X | B2CL1_HUMAN | BCL2-like 1 isoform 1 | BCL2L | BCL2L1 | BCLX | Bcl-2-like protein 1 (Bcl-XL) | Bcl-X | Bcl-xL/Bcl-2-binding component 3 | Bcl2-L-1 | Bcl2-antagonist of cell death (BAD)
Type:
Mitochondrion membrane; Single-pass membrane protein
Mol. Mass.:
26039.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
233
Sequence:
MSQSNRELVVDFLSYKLSQKGYSWSQFSDVEENRTEAPEGTESEMETPSAINGNPSWHLADSPAVNGATGHSSSLDAREVIPMAAVKQALREAGDEFELRYRRAFSDLTSQLHITPGTAYQSFEQVVNELFRDGVNWGRIVAFFSFGGALCVESVDKEMQVLVSRIAAWMATYLNDHLEPWIQENGGWDTFVELYGNNAAAESRKGQERFNRWFLTGMTVAGVVLLGSLFSRK
  
Inhibitor
Name:
BDBM156378
Synonyms:
US9018381, 3 | US9248140, 3
Type:
Small organic molecule
Emp. Form.:
C45H48ClF3N4O7S3
Mol. Mass.:
945.528
SMILES:
CN(CCO)CC[C@H](CSc1ccccc1)Nc1ccc(cc1S(=O)(=O)C(F)(F)F)S(=O)(=O)NC(=O)c1ccc(cc1)N1CCC(CC1)[C@@H](O)c1ccccc1-c1ccc(Cl)cc1 |r|
Structure:
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