Reaction Details Report a problem with these data
Target
Cyclic GMP-AMP synthase
Ligand
BDBM50590388
Substrate
n/a
Meas. Tech.
ChEMBL_2196568 (CHEMBL5109084)
IC50
300±n/a nM
Citation
 Zhao, J; Xiao, R; Zeng, R; He, E; Zhang, A Small molecules targeting cGAS-STING pathway for autoimmune disease. Eur J Med Chem 238:0 (2022) [PubMed] 
Target
Name:
Cyclic GMP-AMP synthase
Synonyms:
2'3'-cGAMP synthase | 2.7.7.86 | CGAS_MOUSE | Cgas | Mab-21 domain-containing protein 1 | Mb21d1 | Synonyms=Mb21d1 | cGAMP synthase | m-cGAS
Type:
PROTEIN
Mol. Mass.:
58224.36
Organism:
Mus musculus
Description:
ChEMBL_119133
Residue:
507
Sequence:
MEDPRRRTTAPRAKKPSAKRAPTQPSRTRAHAESCGPQRGARSRRAERDGDTTEKPRAPGPRVHPARATELTKDAQPSAMDAAGATARPAVRVPQQQAILDPELPAVREPQPPADPEARKVVRGPSHRRGARSTGQPRAPRGSRKEPDKLKKVLDKLRLKRKDISEAAETVNKVVERLLRRMQKRESEFKGVEQLNTGSYYEHVKISAPNEFDVMFKLEVPRIELQEYYETGAFYLVKFKRIPRGNPLSHFLEGEVLSATKMLSKFRKIIKEEVKEIKDIDVSVEKEKPGSPAVTLLIRNPEEISVDIILALESKGSWPISTKEGLPIQGWLGTKVRTNLRREPFYLVPKNAKDGNSFQGETWRLSFSHTEKYILNNHGIEKTCCESSGAKCCRKECLKLMKYLLEQLKKEFQELDAFCSYHVKTAIFHMWTQDPQDSQWDPRNLSSCFDKLLAFFLECLRTEKLDHYFIPKFNLFSQELIDRKSKEFLSKKIEYERNNGFPIFDKL
  
Inhibitor
Name:
BDBM50590388
Synonyms:
CHEMBL5205793
Type:
Small organic molecule
Emp. Form.:
C9H6ClN5O3
Mol. Mass.:
267.629
SMILES:
[O-][N+](=O)c1cn[nH]c1C(=O)Nc1ccc(Cl)cn1
Structure:
Search PDB for entries with ligand similarity: