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Target
Serpin H1
Ligand
BDBM50162505
Substrate
n/a
Meas. Tech.
ChEMBL_305934 (CHEMBL833481)
IC50
3100±n/a nM
Citation
 Thomson, CA; Atkinson, HM; Ananthanarayanan, VS Identification of small molecule chemical inhibitors of the collagen-specific chaperone Hsp47. J Med Chem 48:1680-4 (2005) [PubMed]  Article 
Target
Name:
Serpin H1
Synonyms:
CBP1 | CBP2 | Collagen-binding protein 1 | HSP47 | SERPH_HUMAN | SERPINH1 | SERPINH2
Type:
PROTEIN
Mol. Mass.:
46451.09
Organism:
Homo sapiens (Human)
Description:
ChEMBL_305934
Residue:
418
Sequence:
MRSLLLLSAFCLLEAALAAEVKKPAAAAAPGTAEKLSPKAATLAERSAGLAFSLYQAMAKDQAVENILVSPVVVASSLGLVSLGGKATTASQAKAVLSAEQLRDEEVHAGLGELLRSLSNSTARNVTWKLGSRLYGPSSVSFADDFVRSSKQHYNCEHSKINFRDKRSALQSINEWAAQTTDGKLPEVTKDVERTDGALLVNAMFFKPHWDEKFHHKMVDNRGFMVTRSYTVGVMMMHRTGLYNYYDDEKEKLQIVEMPLAHKLSSLIILMPHHVEPLERLEKLLTKEQLKIWMGKMQKKAVAISLPKGVVEVTHDLQKHLAGLGLTEAIDKNKADLSRMSGKKDLYLASVFHATAFELDTDGNPFDQDIYGREELRSPKLFYADHPFIFLVRDTQSGSLLFIGRLVRPKGDKMRDEL
  
Inhibitor
Name:
BDBM50162505
Synonyms:
6-Chloro-2-oxo-2,3-dihydro-2lambda*4*-benzo[1,2,3]dithiazole-4-carboxylic acid methyl ester | CHEMBL371508
Type:
Small organic molecule
Emp. Form.:
C8H6ClNO3S2
Mol. Mass.:
263.721
SMILES:
COC(=O)c1cc(Cl)cc2SS(=O)Nc12
Structure:
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