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Target
MAP kinase-activated protein kinase 2
Ligand
BDBM50162642
Substrate
n/a
Meas. Tech.
ChEMBL_306157 (CHEMBL832345)
IC50
>200000±n/a nM
Citation
 Anderson, DR; Hegde, S; Reinhard, E; Gomez, L; Vernier, WF; Lee, L; Liu, S; Sambandam, A; Snider, PA; Masih, L Aminocyanopyridine inhibitors of mitogen activated protein kinase-activated protein kinase 2 (MK-2). Bioorg Med Chem Lett 15:1587-90 (2005) [PubMed]  Article 
Target
Name:
MAP kinase-activated protein kinase 2
Synonyms:
MAP kinase-activated protein kinase 2 (MAPKAPK2) | MAP kinase-activated protein kinase 2 (MK2) | MAP kinase-activated protein kinase 2 (p38/MK2) | MAPK-Activated Protein Kinase 2 (MK2) | MAPK-activated protein kinase 2 | MAPK2_HUMAN | MAPKAP kinase 2 | MAPKAPK-2 | MAPKAPK2 | MK2
Type:
Serine/threonine-protein kinase
Mol. Mass.:
45579.87
Organism:
Homo sapiens (Human)
Description:
P49137
Residue:
400
Sequence:
MLSNSQGQSPPVPFPAPAPPPQPPTPALPHPPAQPPPPPPQQFPQFHVKSGLQIKKNAIIDDYKVTSQVLGLGINGKVLQIFNKRTQEKFALKMLQDCPKARREVELHWRASQCPHIVRIVDVYENLYAGRKCLLIVMECLDGGELFSRIQDRGDQAFTEREASEIMKSIGEAIQYLHSINIAHRDVKPENLLYTSKRPNAILKLTDFGFAKETTSHNSLTTPCYTPYYVAPEVLGPEKYDKSCDMWSLGVIMYILLCGYPPFYSNHGLAISPGMKTRIRMGQYEFPNPEWSEVSEEVKMLIRNLLKTEPTQRMTITEFMNHPWIMQSTKVPQTPLHTSRVLKEDKERWEDVKEEMTSALATMRVDYEQIKIKKIEDASNPLLLKRRKKARALEAAALAH
  
Inhibitor
Name:
BDBM50162642
Synonyms:
2,4-Diamino-10,10-dioxo-5,10-dihydro-10lambda*6*-thiochromeno[2,3-b]pyridine-3-carbonitrile | CHEMBL180574
Type:
Small organic molecule
Emp. Form.:
C13H10N4O2S
Mol. Mass.:
286.309
SMILES:
Nc1nc2c(Cc3ccccc3S2(=O)=O)c(N)c1C#N
Structure:
Search PDB for entries with ligand similarity: